Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Osei-Owusu, Jonathan; Aidoo, Owusu Fordjour; Eshun, Fatima; Gaikpa, David Sewordor; Dofuor, Aboagye Kwarteng; Vigbedor, Bright Yaw; Turkson, Bernard Kofi; Ochar, Kingsley; Opata, John; Opoku, Maxwell Jnr.; Ninsin, Kodwo Dadzie; Borgemeister, Christian

doi:10.1016/j.heliyon.2023.e22018

Cited by 2 publications

(2 citation statements)

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“…Considered by the World Health Organization (WHO) a skinrelated neglected tropical disease, 1 Buruli ulcer is predominantly linked with poverty and disadvantage, afflicting rural communities across west and central Africa. 2 In 2004, the year Buruli ulcer become notifiable in Victoria, there were 26 human cases of this little-known condition reported across the state. Most of those 26 cases clustered around the small, Victorian seaside town of Point Lonsdale.…”

Section: Introductionmentioning

confidence: 99%

“…Readers are referred to several excellent, recent reviews on the range of issues surrounding Buruli ulcer. 2,4,[8][9][10][11][12][13] The focus on this current article is a summary of efforts to address the 80-year mystery of how M. ulcerans is spreading from the environment to humans in south-eastern Australia; where a One Health perspective has become so critical to help understand why there are surging local case numbers in Victoria (and beyond) and why the pathogen is spreading.…”

Section: Introductionmentioning

confidence: 99%

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The buzz around the zoonotic infection, Buruli ulcer

O’Brien,

Stinear

2024

Microbiol. Aust.

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Here, we provide an update on the significant progress towards understanding transmission of Mycobacterium ulcerans, the causative agent of the neglected tropical skin disease, Buruli ulcer. We review the evidence that Buruli ulcer is an enzootic infection among Australian native possums, and we discuss the role of mosquitoes in transmit the infection to humans. We show how studies of M. ulcerans transmission – following the dramatic emergence of Buruli ulcer in temperate south-eastern Australia – are being supported by adherence to One Health principles, with interdisciplinary research teams uncovering connections between human health, animal health, and the environment. We also discuss some of the distinctive features of M. ulcerans revealed by genomics that should be considered when thinking about how this pathogen is spreading.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The buzz around the zoonotic infection, Buruli ulcer

O’Brien,

Stinear

2024

Microbiol. Aust.

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Buruli ulcer in Australia: Evidence for a new endemic focus at Batemans Bay, New South Wales

Hossain,

Keighley,

Buultjens

et al. 2024

PLoS Negl Trop Dis

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We describe two locally acquired cases of Mycobacterium ulcerans infection (Buruli ulcer) in the town of Batemans Bay on the east coast of New South Wales (NSW), Australia, 150 km north of Eden, the only other place in NSW where Buruli ulcer has likely been locally acquired. Genomic analysis showed that the bacterial isolates from the cases were identical but belonged to a phylogenetically distinct M. ulcerans clade that was most closely related to the isolate from the earlier case in Eden to the south. It is proposed that Batemans Bay is a new endemic focus of human Buruli ulcer transmission.

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Buruli ulcer in Africa: Geographical distribution, ecology, risk factors, diagnosis, and indigenous plant treatment options – A comprehensive review

Cited by 2 publications

References 97 publications

The buzz around the zoonotic infection, Buruli ulcer

The buzz around the zoonotic infection, Buruli ulcer

Buruli ulcer in Australia: Evidence for a new endemic focus at Batemans Bay, New South Wales

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