Buschke-Löwenstein tumour (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight

Abstract

Buschke Löwenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. BLT/GCA is characterized by verrucous tumor or palpable cauliflower-likemass, exophytic growth, flesh-colored, and uneven surface. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.

Relationship between Clusters of Differentiation 4 Count and Type of Human Papilloma Virus with Giant Condyloma Acuminata

“…GCA is usually benign, cauliflower-shaped lesions, located in the anogenital region with a diameter of more than 2.5 cm, and can reach a size of 10-15 cm. GCA was first described by Abraham Buschke and Lowenstein Ludwig in 1896 as a penile lesion similar to CA and squamous cell carcinoma with biologic characteristics and different histopathology [3], [4], [5], [6], [7], [8].…”