Buschke-Ollendorff syndrome

Depressed indurated plaque with elastorrhexis as a distinctive lesion in Buschke‐Ollendorff syndrome

“…Skin lesions in BOS appear in early childhood as asymptomatic yellowish or skin‐colored papules or plaques in the extremities and trunk. The lesions may increase in size and number with age, although some may resolve spontaneously . Bone lesions manifest after childhood as asymptomatic multiple, round sclerotic formations known as osteopoikilosis located on long bones, hands, and feet.…”

“…The lesions may increase in size and number with age, although some may resolve spontaneously. 1,2 Bone lesions manifest after childhood as asymptomatic multiple, round sclerotic formations known as osteopoikilosis located on long bones, hands, and feet. Histologic features are often distinctive, consisting of thickened elastic fibers that encase dermal collagen.…”

“…It is characterized by connective tissue nevi and sclerotic bone lesions . The clinical expression of BOS within affected members of the same family is variable, and some patients may present only skin or bone lesions …”