The article examines the reasons determining the intensification of the crisis of labor relations in contemporary conditions. Considering the crisis of labor relations as a permanent phenomenon inherent in the socio-economic system, periodically facing bifurcation points. Its systemic features associated with the loss of the meaningful function of labour due to cardinal changes in productive forces and production processes are highlighted. The necessity of institutional environment transformation ensuring organization of labour activity directly related to the features of economic culture, traditions, values, rules and norms of the socio-economic environment is justified. The discrepancy between environmental conditions and objective transformations of the economy leads to the devaluation of labor, a decrease in its productivity against the backdrop of widespread double morality, as a reaction of workers to transformations that require a revision of their attitude towards work and its intensification. Under these conditions we observe a transformation of work from a way of life into a means of survival, projecting ideas and personal assessments of changes in the labor sphere, causing a widespread crisis in labor relations. In modern conditions of the emergence of the digital economy, new opportunities are opening up to accelerate innovative processes in the labor sphere. However, this contributes to the disruption of the balanced state of the national economic system when it passes the bifurcation point, provoking a crisis in labor relations. This is widely confirmed in practice and requires the development of a systematic understanding of this phenomenon. Modeling a national economy in a state of socio-economic transformation and a crisis in labor relations in accordance with the principle of methodological systematics allows us to holistically present, scientifically substantiate and develop practical recommendations for its overcoming.