Semantic Information Systems (IS) Standards play a critical role in the development of the networked economy. While their importance is undoubted by all stakeholders-such as businesses, policy makers, researchers, developers-the current state of research leaves a number of questions unaddressed. Terminological confusion exists around the notions of ''business semantics'', ''business-to-business interoperability'', and ''interoperability standards'' amongst others. And, moreover, a comprehensive understanding about the characteristics of Semantic IS Standards is missing. The paper addresses this gap in literature by developing a characteristics framework for Semantic IS Standards. Two case studies are used to check the applicability of the framework in a ''real-life'' context. The framework lays the foundation for future research in an important field of the IS discipline and supports practitioners in their efforts to analyze, compare, and evaluate Semantic IS Standards.