Business Planning in Biobanking: How to Implement a Tool for Sustainability

Ciaburri, Mirella; Napolitano, Mariarosaria; Bravo, Elena

doi:10.1089/bio.2016.0045

Cited by 25 publications

(18 citation statements)

References 38 publications

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“…When Ethical Tissue was founded in 2007 the aims were a) to provide a researcher led tissue supply service across most diseases and conditions, b) to make it as simple as possible for researchers to access tissues, c) to maximise tissue supply and minimise tissue banking, "supply not store" and d) to be self-sustaining through a cost recovery model [1] Sustainability and sound business planning has become increasingly important due to constrained budgets in higher education institutes and elsewhere [2,3]. Currently ET recovers over 80% of its costs through service charges to researchers.…”

Section: Project Descriptionmentioning

confidence: 99%

Ethical Tissue: A Bioresource Specialising in Broad Prospective Supply of Tissue from a Wide Range of Participants

Adams

Burrill

Mullarkey

2020

Open Journal of Bioresources

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Ethical Tissue (ET) is a Research Tissue Bank specialising in researcher led prospective collection of tissues. ET does not focus on specific conditions nor is it restricted in who it can supply. We consider requests for any type of tissue, including biofluids such as blood, serum, plasma and urine, from researchers in academia or industry from any part of the world. Tissues and biofluids are collected under generic and lasting consent, maximising reuse/sharing potential. ET also provides tissue processing services including tissue micro-arrays from both fresh frozen tissues and FFPE blocks, primary cell cultures, subcellular fractions and DNA/RNA preparations. A list of banked tissues, including biofluids, cell lines and processed samples is available on the ET website.

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Section: Project Descriptionmentioning

confidence: 99%

Ethical Tissue: A Bioresource Specialising in Broad Prospective Supply of Tissue from a Wide Range of Participants

Adams

Burrill

Mullarkey

2020

Open Journal of Bioresources

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“…Literature about biobanks explores feasibility and implementation for establishing biobanks, including business plans and models for facilitating biobank creation, 43 how to recruit and obtain consent (particularly among particular groups of patients such as cancer patients), [44][45][46] and the use of electronic consent in biobanking. 47 Increasingly, biobanks are augmenting their survey data with EHR database connections.…”

Section: Feasibility and Implementationmentioning

confidence: 99%

The Emerging Landscape of Epidemiological Research Based on Biobanks Linked to Electronic Health Records: Existing Resources, Analytic Challenges and Potential Opportunities

Beesley¹,

Salvatore²,

Fritsche³

et al. 2018

Preprint

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Biobanks linked to electronic health records provide a rich data resource for health-related research. With the establishment of large-scale infrastructure, the availability and utility of data from biobanks has dramatically increased over time. As more researchers become interested in using biobank data to explore a diverse spectrum of scientific questions, resources guiding the data access, design, and analysis of biobank-based studies will be crucial.  The first aim of this review is to characterize the types of biobanks that are discussed in the recent literature and provide detailed descriptions of specific biobanks including their location, size, data access, data linkages and more. The development and accessibility of large-scale biorepositories provide the opportunity to accelerate agnostic searches, new discoveries, and hypothesis-generating studies of disease-treatment, disease-exposure and disease-gene associations. Rather than spending time and money designing and implementing a single study with pre-defined objectives, researchers can use biobanks’ existing data-rich resources to answer scientific questions as quickly as they can analyze them. While the data are becoming increasingly available, additional thought is needed to address issues related to the design of such studies and analysis of these data. In the second aim of this review, we discuss statistical issues related to biobank research in general including study design, sampling strategy, phenotype identification, and missing data. These issues are illustrated using data from the Michigan Genomics Initiative, UK Biobank, and Genes for Good. We summarize the current body of statistical literature aimed at addressing some of these challenges and discuss some of the standing open problems in this area. This work serves to complement and extend recent reviews about biobank-based research and aims to provide a resource catalog with statistical and practical guidance to researchers pursuing biobank-based research.

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“…It is also true that biobanks have been subject to considerable political concern, where the economics of biobanking initiatives have not been well understood, often resulting in substantial costs (Ciaburri, Napolitano, & Bravo, 2017;Gee, Oliver, Corfield, Georghiou, & Yuille, 2015;. Hence, there has been an increased political incentive to expand development and operation resources to ensure long-term sustainability of biobanks, while at the same time maximising their impact (Meijer et al, 2012;Vaught, Rogers, Carolin, & Compton, 2011).…”

Section: The Biobanking Situationmentioning

confidence: 99%

The 4 I’s of Entrepreneurship: A Study of the Entrepreneurial Perspectives behind A Failed Large-Scale Distributed Research Infrastructure

Larsson

2018

Entrepreneurship Research Journal

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This case study investigates whether collective entrepreneurial team cognition remains consistent throughout all stage processes when setting up a large-scale, distributed research infrastructure. A new “action phase model” has been devised, known as the “4 I’s of entrepreneurship”, with each “I” elucidating the entrepreneurial rationale behind various stages of the creation process: Intention, Initiation, Implementation and Introspection. The case investigated was BBMRI.se (BioBanking and Molecular Resource Infrastructure in Sweden) – a Swedish large-scale distributed research infrastructure aimed at harmonizing biobanking standards. Managers and key personnel involved in founding and/or operating the organization were interviewed. The results showed there was agreement regarding the need for the research infrastructure, while there were disagreeing perceptions of what the organization should be doing and regarding the difficulties it had faced. These developments would ultimately lead to BBMRI.se’s demise. The homogenous mindset would begin to dissipate once the Initiation stage was reached and worsened throughout the Implementation stage. The results indicate that BBMRI.se’s managerial structure, personal ambitions and lack of transparency and communication were key contributors to its ultimate failure. The implications highlight the risk of fragmented motivations as collective entrepreneurs turn their ambition into reality, if given too much autonomy.

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Business Planning in Biobanking: How to Implement a Tool for Sustainability

Cited by 25 publications

References 38 publications

Ethical Tissue: A Bioresource Specialising in Broad Prospective Supply of Tissue from a Wide Range of Participants

Ethical Tissue: A Bioresource Specialising in Broad Prospective Supply of Tissue from a Wide Range of Participants

The Emerging Landscape of Epidemiological Research Based on Biobanks Linked to Electronic Health Records: Existing Resources, Analytic Challenges and Potential Opportunities

The 4 I’s of Entrepreneurship: A Study of the Entrepreneurial Perspectives behind A Failed Large-Scale Distributed Research Infrastructure

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