Purpose: Innovation is the key to success for businesses and it remains a crucial element in the sustainable development of the entrepreneurship activities across the globe. It is characterized by the creative capacity of invention as a source of sociocultural and technological change. In this background, the current review provides an overview of innovative business practices, enablers, and the factors that prevent the business owners to innovate new product/ service offerings, role of innovation among the small and medium enterprises, and impact of innovative business practices in the aftermath of COVID-19. Methodology: No comprehensive review has been made in this domain, though the researchers have focused on the concepts of innovation and business practices separately. The present study is an important contribution to the research domain as it holistically approaches the concept, its application, and the takeaway for future. Findings: The research article reviewed the studies conducted earlier and discussed the innovative practices followed in different domains and how the existing studies handled the concept of innovation in business. The paper also discussed about green innovation concepts and the concept of business innovation in India since India emerges as a vibrant nation after COVID-19. Implications: As per the India Innovation Index 2021, India is yet to tap the potential areas. With loads of opportunities yet to be unleashed, India must bring policy measures to make business innovations, a norm. It has increased continuously in the ladder of innovative start-up environment provider, though there is a scope for further growth in this regard.