Butanol Extract of <i>Acanthopanax senticosus</i> (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Jia, Ailing; Shi, Yue; Zhang, Yuhang; Diao, Yuan-Yuan; Chang, Bai-Jin; Jiang, Mi; Liu, Weipeng; Qiu, Zhidong; Fu, Chaomei; Qiu, Ye

doi:10.1002/cbdv.202200949

Cited by 3 publications

(1 citation statement)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same S. baicalensis may play a therapeutic role by modulating cholesterol biosynthesis and sphingolipid metabolic pathways ( 135 ). In addition, rhubarb and gypenoside, a butanol extract of Acanthopanax senticosus, have been studied and shown to have significant lipid-lowering effects ( 136 – 138 ). Certain herbal formulations, including Dingxin Recipe IV, DiDang decoction, Yindanxinnaotong, and Shengmai Yin, exhibit potential efficacy in enhancing lipid metabolism and providing resistance to atherosclerosis (136–139) ( 139 – 142 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023

Tan,

Wang,

Chen

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundWhile Traditional Chinese Medicine (TCM) boasts an extensive historical lineage and abundant clinical expertise in addressing atherosclerosis, this field is yet to be penetrated adequately by bibliometric studies. This study is envisaged to evaluate the contemporary scenario of TCM in conjunction with atherosclerosis over the preceding decade while also identifying forthcoming research trends and emerging topics via the lens of bibliometric analysis.MethodsLiterature pertaining to TCM and atherosclerosis, circulated between January 1, 2012 and November 14, 2023, was garnered for the purpose of this research. The examination embraced annual publications, primary countries/regions, engaged institutions and authors, scholarly journals, references, and keywords, utilizing analytical tools like Bibliometrix, CiteSpace, ScimagoGraphica, and VOSviewer present in the R package.ResultThis field boasts a total of 1,623 scholarly articles, the majority of which have been contributed by China in this field, with significant contributions stemming from the China Academy of Traditional Chinese Medicine and the Beijing University of Traditional Chinese Medicine. Moreover, this field has received financial support from both the National Natural Science Foundation of China and the National Key Basic Research Development Program. Wang Yong tops the list in terms of publication count, while Xu Hao's articles take the lead for the total number of citations, positioning them at the core of the authors’ collaborative network. The Journal of Ethnopharmacology leads with the most publications and boasts the greatest total number of citations. Principal research foci within the intersection of Chinese Medicine and Atherosclerosis encompass disease characteristics and pathogenic mechanisms, theoretical underpinnings and syndrome-specific treatments in Chinese medicine, potentialities of herbal interventions, and modulation exerted by Chinese medicines on gut microbiota.ConclusionThis analysis offers a sweeping survey of the contemporary condition, principal foci, and progressive trends in worldwide research related to Traditional Chinese Medicine (TCM) and atherosclerosis. It further delves into an in-depth dissection of prominent countries, research institutions, and scholars that have made noteworthy strides in this discipline. Additionally, the report analyzes the most cited articles, research developments, and hotspots in the field, providing a reference for future research directions for clinical researchers and practitioners.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023

Tan,

Wang,

Chen

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

Dai,

Qiu,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the leading cause of human mortality worldwide. Despite Western medicine having made encouraging results in the clinical management of CVD, the morbidity, mortality, and disability rates of the disease remain high. Modern pharmacology has confirmed that traditional Chinese medicine (TCM), characterized by its multi-component, multi-target, and integrity, plays a positive and important role in the prevention and treatment of various CVDs in China, which has notable advantages in stabilizing disease, improving heart function, and enhancing the quality of life. Importantly, TCM is gradually being accepted by the international community due to its low cost, high safety, versatile bioactivity, and low toxicity. Unfortunately, comprehensive studies on the therapeutic effect of TCM on CVD and its mechanisms are very limited, which may restrict the clinical application of TCM in CVD. Therefore, this review is performed to analyze the pathogenesis of CVD, including inflammatory response, oxidative stress, mitochondrial dysfunction, pyroptosis, ferroptosis, dysbiosis of gut microbiota, etc. Moreover, we summarized the latest progress of TCM (formulas, extracts, and compounds) in curing CVD according to published literature from 2018 to 2023, as well as its mechanisms and clinical evidence. In conclusion, this review is expected to provide useful information and reference for the clinical application of TCM in the prevention and treatment of CVD and further drug development of CVD.

show abstract

A review of the extraction and purification methods, biological activities, and applications of active compounds in Acanthopanax senticosus

Zhang,

Guan,

Zhu

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

Acanthopanax senticosus (AS) is a geo-authentic crude medicinal plant that grows in China, Korea, Russia, and Japan. AS contains bioactive compounds such as eleutherosides, polysaccharides, and flavonoids. It is also a key traditional herb in the Red List of Chinese Species. AS is mainly distributed in Northeast China, specifically in Heilongjiang, Jilin, and Liaoning provinces. Its active compounds contribute to significant biological activities, including neuroprotective, antioxidant, anti-fatigue, and antitumor effects. However, the extraction methods of active compounds are complex, the extraction efficiency is poor, and the structure–activity relationship is unclear. This study focused on the nutrients in AS, including protein, carbohydrates, and lipids. Particularly, the active ingredients (eleutherosides, polysaccharides, and flavonoids) in AS and their extraction and purification methods were analyzed and summarized. The biological activities of extracts have been reviewed, and the mechanisms of anti-oxidation, antitumor, anti-inflammation, and other activities are introduced in detail. The applications of AS in various domains, such as health foods, medicines, and animal dietary supplements, are then reported. Compared with other extraction methods, ultrasonic or microwave extraction improves efficiency, yet they can damage structures. Challenges arise in the recovery of solvents and in achieving extraction efficiency when using green solvents, such as deep eutectic solvents. Improvements can be made by combining extraction methods and controlling conditions (power, temperature, and time). Bioactive molecules and related activities are exposited clearly. The applications of AS have not been widely popularized, and the corresponding functions require further development.

show abstract

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Cited by 3 publications

References 61 publications

Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023

Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023

Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms

A review of the extraction and purification methods, biological activities, and applications of active compounds in Acanthopanax senticosus

Contact Info

Product

Resources

About