Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats

Bajaj, Payal; Singh, Harpal; Kalotra, Shikha; Kaur, Gurcharan

doi:10.1007/s12017-021-08683-x

Cited by 9 publications

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“…A previous study from our lab also reported that TCP supplementation ameliorated the obesity-induced anxiety-like behavior in young 3–4 months old female rats ( Singh et al, 2021 ). Similarly, in acute sleep-deprived middle-aged female rats, the B-TCE fraction of T. cordifolia was observed to improve the cognitive functioning of middle-aged female rats ( Bajaj et al, 2021 ).…”

Section: Discussionmentioning

confidence: 98%

“…A transcriptome study from centenarians revealed that the expression of the Bcl-xL gene was upregulated in centenarians compared to septuagenarians and was involved in the regulation of apoptosis, immune responses, and cellular damage control, leading to exceptional aging ( Borras et al, 2016 ). In our previous lab report, TCP supplementation in young adult rats was observed to ameliorate HFD-induced apoptosis in the hippocampus and the PFC regions of the brain ( Singh et al, 2021 ), and one active fraction of T. cordifolia , i.e., B-TCE also was effective to ameliorate the acute-sleep deprivation-induced apoptosis in the middle-aged female rats ( Bajaj et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Butanol extract of T. cordifolia (B-TCE) and one of its actives, Tinosporicide, ameliorated glutamate-mediated excitotoxic response in the hippocampus, and cerebellar primary neurons ( Sharma and Kaur, 2018 ; Sharma et al, 2020b ). TCE and B-TCE were reported to show anxiolytic effects as well as an improvement in cognitive functions in a model of acute-sleep-deprivation rodents ( Mishra et al, 2016 ; Bajaj et al, 2021 ). Similarly, cognitive function impairments induced by HFD feeding-related obesity in young adult rats were ameliorated with the supplementation of dry stem powder of T. cordifolia (TCP) in their diet ( Singh et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats

Bhandari

Sunkaria

Kaur

2022

Front. Aging Neurosci.

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The midlife transition period in women marks the progressive flattening of neurological health along with increased adiposity, dyslipidemia, frailty, and inflammatory responses mainly attributed to the gradual decline in estrogen levels. Conflicting reports of hormone replacement therapy (HRT) necessitate the exploration of novel therapeutic interventions using bioactive natural products having the least toxicity and a holistic mode of action for the preservation of metabolic homeodynamics with aging in women. The present study was planned to investigate the effects of aging and/or a high-fat diet (HFD) on cognitive impairments and anxiety and further their management by dietary supplement with the Tinospora cordifolia stem powder (TCP). Acyclic female rats were included in this study as the model system of the perimenopause phase of women along with young 3–4 months old rats as controls. Rats were fed on with and without TCP supplemented normal chow or HFD for 12 weeks. Animals fed on a TCP supplemented normal chow showed consistent management of body weight over a 12-week regimen although their calorie intake was much higher in comparison to their age-matched controls. Post-regimen, neurobehavioral tests, such as novel object recognition and elevated plus maze, performed on these animals showed improvement in their learning and memory abilities as well as the anxiety-like behavior. Furthermore, due to the presence of multiple components, TCP was observed to modulate the expression of key marker proteins to ameliorate neuroinflammation and apoptosis and promote cell survival and synaptic plasticity in the hippocampus and the prefrontal cortex (PFC) regions of the brain. These findings suggest that TCP supplementation in diet during the midlife transition period in women may be a potential interventional strategy for the management of menopause-associated anxiety and cognitive impairments and healthy aging.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats

Bhandari

Sunkaria

Kaur

2022

Front. Aging Neurosci.

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“…Yapılan çalışmalar KSH'un glial aktivasyonu, reaktif oksijen türlerinin (ROS) oluşumunu, mitokondrial disfonksiyonu, nöroinflamasyonu, kan beyin bariyeri (KBB) hasarını, beyaz cevher lezyonunu, tau hiperfosforilasyonunu, amiloid beta (Aβ) birikimini artırarak nörodejenerasyona ve sonuçta da nöronal hasara yol açabileceğini göstermektedir (1,2). Ayrıca bu değişiklikler öğrenme ve hafızayla ilişkili hipokampüs ve prefrontal korteks (PFC)'de anormal beyin yapısı ve işlevine yol açarak bilişsel bozulmaya neden olmaktadır (3,4). KSH sıçanlarda bilateral ortak karotid arterlerin kalıcı oklüzyonu (2VO) ile indüklenebilmektedir ve serebrovasküler bozuklukların patofizyolojisini araştırmak için deneysel çalışmalarda sıklıkla kullanılmaktadır (5).…”

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Cerrahi Menopoz ve Kronik Serebral Hipoperfüzyon Oluşturulmuş Sıçanlarda Spironolaktonun Prefrontal Korteks ve Göz Dokularında Glikojen ve Oksidatif Stres Parametreleri Üzerine Etkisi

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et al. 2022

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Aim: Chronic cerebral hypoperfusion (CCH) leads to vascular dementia with progressive hippocampal damage and cognitive impairments. CCH also causes a decrease in blood flow in the retina.The aim of this study was to investigate the effects of spironolactone on oxidative stress and glycogen levels in the eye and prefrontal cortex (PFC) tissues in ovariectomized rats with CCH. Material and Methods: 32 female Wistar Albino rats were randomly divided into 4 groups, 8 in each group: 1)Control, 2)KSH, 3) KSH+Spironolactone 25mg/kg 4)KSH+Spironolactone 50mg/kg. The rats underwent bilateral ovariectomy (OVX) at the start of the experiment, a CCH model was created with permanent occlusion of the common carotid arteries (2VO) 5 weeks after OVX. Spironolactone was administered by oral gavage three days before 2VO and once daily for 3 weeks after 2VO. At the end of the experiment, tissue glycogen, reduced glutathione (GSH), malondialdehyde (MDA) and ascorbic acid (AA) levels were measured. Statistical analysis was performed using ANOVA and Bonferroni tests. Results: CCH caused an increase in oxidative stress markers and a decrease in glycogen level in PFC. Similarly, CCH caused a decrease in both glycogen and AA levels in the eye tissue. In the group treated with 25mg/kg spironolactone, the AA and PFC glycogen levels of the eyes decreased, while the MDA levels in the PFC were increased compared to the CCH group(p

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Tinospora cordifolia as a Potential Candidate for Health Care of Post-Menopausal Women

Bhandari

Kaur

2023

Sustainable Development and Biodiversity

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Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats

Cited by 9 publications

References 46 publications

Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats

Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats

Cerrahi Menopoz ve Kronik Serebral Hipoperfüzyon Oluşturulmuş Sıçanlarda Spironolaktonun Prefrontal Korteks ve Göz Dokularında Glikojen ve Oksidatif Stres Parametreleri Üzerine Etkisi

Tinospora cordifolia as a Potential Candidate for Health Care of Post-Menopausal Women

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