Butanol production in acetone-butanol-ethanol fermentation with in situ product recovery by adsorption

Xue, Chuang; Liu, Fangfang; Xu, Mengmeng; Tang, I‐Ching; Zhao, Jun; Bai, Feng‐Wu; Yang, Shang‐Tian

doi:10.1016/j.biortech.2016.07.111

Cited by 129 publications

(94 citation statements)

References 41 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…zeolites or activated carbon. It is a rather easy to use technique, requires generally little energy compared with other alternatives, does not damage bacterial cells and is effective in separating solvents such as butanol from the medium . Liquid–liquid extraction consists in using a solvent with a high extraction efficiency for the metabolites to be separated from the fermentation broth.…”

Section: Production Of (Higher) Alcohols From Co‐rich Gasesmentioning

confidence: 99%

H‐B‐E (hexanol‐butanol‐ethanol) fermentation for the production of higher alcohols from syngas/waste gas

Fernández-Naveira

Veiga

Kennes

2017

J of Chemical Tech & Biotech

117

View full text Add to dashboard Cite

CO, H2, and CO2 are major components of syngas and some industrial CO‐rich waste gases (e.g. waste gases from steel industries), besides some additional minor compounds. It was recently shown that those gases can be bioconverted, by acetogenic/solventogenic bacteria, into ethanol and higher alcohols such as butanol, but also hexanol, through the so‐called HBE fermentation. That process presents some advantages over existing chemical conversion processes. This paper reviews HBE fermentation from C1‐gases after briefly describing the more conventional ABE (acetone‐butanol‐ethanol) fermentation from carbohydrates by Clostridium acetobutylicum, in order to allow for comparison of both processes. Although acetone may appear in carbohydrate fermentation, alcohols are the only major end‐metabolites in the HBE process with Clostridium carboxidivorans. The few acetogenic bacteria known to metabolize C1‐gases and produce butanol or higher alcohols are described. Clostridium carboxidivorans has been used in most cases. Bioconversion of the gaseous substrates takes place in two stages, namely acidogenesis (production of acids) followed by solventogenesis (production of alcohols), characterized by different optimal fermentation conditions. Major parameters affecting each bioconversion stage as well as the overall fermentation process are analyzed. Although it has been claimed that acidification is required in ABE fermentation to initiate the solventogenic stage, strong acidification seems to some extent not to be a prerequisite for solventogenesis in the HBE process. Bioreactors potentially suitable for this type of bioconversion process are described as well. © 2017 Society of Chemical Industry

show abstract

Section: Production Of (Higher) Alcohols From Co‐rich Gasesmentioning

confidence: 99%

H‐B‐E (hexanol‐butanol‐ethanol) fermentation for the production of higher alcohols from syngas/waste gas

Fernández-Naveira

Veiga

Kennes

2017

J of Chemical Tech & Biotech

117

View full text Add to dashboard Cite

show abstract

“…This implies that a high permeation flux is particularly important in practical production in terms of economic viability. The αs for other membranes made in laboratories were high, clearly because of a low concentration of feed solution (ca. 1 wt %), which was inversely proportional to α.…”

Section: Resultsmentioning

confidence: 99%

Preparation of polymer of intrinsic microporosity composite membranes and their applications for butanol recovery

Lan

Peng

2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

We fabricated novel composite membranes composed of a polymer of intrinsic microporosity (PIM‐1) and carbon black (CB) nanoparticles functionalized with the silane coupling agent aminopropyl triethoxysilane to recover butanol from aqueous solutions by pervaporation (PV). Scanning electron microscopy showed that the composite membranes were dense and defect free and had good adhesion with substrates. Compared with the those of pristine PIM‐1 membranes, the water contact angles of the composite membranes increased from around 86° to more than 90°; this confirmed the improvement of the hydrophobicity. The swelling degree of the 6 wt % CB‐filled PIM‐1 membranes dropped 23%; this indicated an increase in the swelling resistance. Furthermore, the PV results show experimentally that the incorporation of the functionalized CBs into the PIM‐1 matrix considerably improved both the permeability and selectivity to butanol. At a 4 wt % CB content, the optimum separation performance, with a separation factor of 19.7 and a permeation flux of 1116 g m−2 h−1, was achieved in an aqueous solution containing 5 wt % butanol at 30°C. It was noteworthy that the as‐fabricated membranes exhibited a good separation stability. This is a step forward in terms of continuous butanol production with hybrid membranes in fermentation processes. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46912.

show abstract

“…Xue et al . reported a succession of various methods for the recovery of butanol produced by Clostridium acetobutylicum , such as gas stripping3738, adsorption35, and a vapour stripping-vapour permeation (VSVP) process36. When gas stripping was applied intermittently in fed-batch fermentation, 195.9 g/L acetone-butanol-ethanol or 150.5 g/L butanol was obtained, and furthermore, energy consumption and water usage was reduced by at least 90%.…”

Section: Discussionmentioning

confidence: 99%

The metabolic flux regulation of Klebsiella pneumoniae based on quorum sensing system

Sun

Zhang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Quorum-sensing (QS) systems exist universally in bacteria to regulate multiple biological functions. Klebsiella pneumoniae, an industrially important bacterium that produces bio-based chemicals such as 2,3-butanediol and acetoin, can secrete a furanosyl borate diester (AI-2) as the signalling molecule mediating a QS system, which plays a key regulatory role in the biosynthesis of secondary metabolites. In this study, the molecular regulation and metabolic functions of a QS system in K. pneumoniae were investigated. The results showed that after the disruption of AI-2-mediated QS by the knockout of luxS, the production of acetoin, ethanol and acetic acid were relatively lower in the K. pneumoniae mutant than in the wild type bacteria. However, 2,3-butanediol production was increased by 23.8% and reached 54.93 g/L. The observed enhancement may be attributed to the improvement of the catalytic activity of 2,3-butanediol dehydrogenase (BDH) in transforming acetoin to 2,3-butanediol. This possibility is consistent with the RT-PCR-verified increase in the transcriptional level of budC, which encodes BDH. These results also demonstrated that the physiological metabolism of K. pneumoniae was adversely affected by a QS system. This effect was reversed through the addition of synthetic AI-2. This study provides the basis for a QS-modulated metabolic engineering study of K. pneumoniae.

show abstract

Butanol production in acetone-butanol-ethanol fermentation with in situ product recovery by adsorption

Cited by 129 publications

References 41 publications

H‐B‐E (hexanol‐butanol‐ethanol) fermentation for the production of higher alcohols from syngas/waste gas

H‐B‐E (hexanol‐butanol‐ethanol) fermentation for the production of higher alcohols from syngas/waste gas

Preparation of polymer of intrinsic microporosity composite membranes and their applications for butanol recovery

The metabolic flux regulation of Klebsiella pneumoniae based on quorum sensing system

Contact Info

Product

Resources

About