Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice

Zheng, Wenhao; Zhang, Hui; Jin, Yonglong; Wang, Quan; Chen, Linwei; Feng, Zhenhua; Chen, Hua; Wu, Yaosen

doi:10.1016/j.intimp.2016.11.009

Cited by 81 publications

(58 citation statements)

References 43 publications

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“…For the first time, we report the degree of synovitis and its heritability in RI strains following DMM surgery. Cartilage degeneration and synovitis were strongly coupled across strains, although the correlations were not absolute. Clinically, it is reported that synovitis is related to the severity of pain in OA .…”

Section: Discussionmentioning

confidence: 93%

Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice

Chinzei

Farooq

Hashimoto

et al. 2019

Arthritis & Rheumatology

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For these mouse strains, various characteristics of PTOA varied with genetic composition demonstrating a genetic basis for PTOA susceptibility. The heritability of PTOA was established. Phenotypes exhibited various degrees of correlations: (1) cartilage degeneration is positively correlated with synovitis, but (2) not with the formation of ectopic calcification. Further investigation of the regions of genome containing genes implicated in OA and expression data will be useful for studying mechanisms of OA and identifying therapeutic targets. This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 93%

Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice

Chinzei

Farooq

Hashimoto

et al. 2019

Arthritis & Rheumatology

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“…Recent studies have demonstrated that the inflammatory process is of vital importance during the destruction of cartilage, which is a characteristic of OA . Yusuf et al found that a higher level of adiponectin was associated with a lower risk of hand OA progression in an observational follow‐up study .…”

Section: Discussionmentioning

confidence: 99%

Association between body composition and osteoarthritis: A systematic review and meta‐analysis

et al. 2019

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| INTRODUC TI ONOsteoarthritis (OA) is a prevalent joint degenerative disease and the major cause of disability for the elderly population worldwide. In the USA, over 20 million of people suffer from OA and this figure is estimated to double over the next two decades. 1 The main symptom of OA is chronic musculoskeletal pain, which is associated with physical disability and dysfunction. 2,3 The major treatments for OA include pain alleviation and improvement of functional activity, and for end-stage patients, joint replacement is often needed. 4-6 Many factors may increase the risk of OA, such as metabolic factors, mechanical factors, and inflammatory factors, 7 among which, obesity is considered the most important one. 8 Meanwhile, the prevalence of obesity, which leaves the affected population vulnerable to multiple comorbidities, 9 has been growing alarmingly all over the world. 10,11 Recently, a lot of attention has been paid by the academic circle to the association between obesity and OA in view of its high prevalence and modifiable status. Felson et al reported that obese AbstractObjectives: To examine the association between body composition and osteoarthritis (OA).Methods: An extensive literature review was performed to identify studies that examined the association between body composition and OA. The mean difference (MD), odds ratio (OR), relative risk (RR) and corresponding 95% confidence intervals (CIs) were determined using RevMan statistical software. Results:A total of 19 studies were included. The combined MD showed the fat mass of the subjects with knee OA was higher than that of the control group (MD 4.38,). Both fat mass and fat mass percentage were positively associated with knee OA (ORs ranged from 1.49, 95% CI: 1.15-1.92, to 2.37, 95% CI: 1.18-4.74).Similar findings were observed in hip and hand joints as well (ORs ranged from 1.20, 95% CI: 1.08-1.32, to 1.87, 95% CI: 1.11-3.15), and such results were also confirmed by most cohort studies of knee and hip OA (RRs ranged from 0.98, 95% CI: 0.95-1.01, to 3.60, 95% CI: 2.60-5.00). Lean mass was also positively associated with knee OA (OR 1.48, 95% CI: 1.13-1.94). However, lean mass percentage was negatively associated with knee OA (OR 0.65, 95% CI: 0.46-0.92). Conclusions:Both fat mass and fat mass percentage were likely to be risk factors for knee, hip and hand OA. Similarly, lean mass also seemed to be a risk factor for knee OA, while lean mass percentage seemed to be a protective factor. K E Y W O R D Sbody composition, fat mass, lean mass, meta-analysis, osteoarthritis

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“…PGE2, a principal mediator of inflammation, is converted from endogenous arachidonic acid induced by IL-1β via COX-2 catalytic reactions and is associated with cartilage destruction due to its powerful activation for MMPs and other inflammatory mediators [34,35]. All of these factors, as well as TNF-α and IL-6, are important inflammatory cytokines in OA development [36]. In this study, we found that overproduction of PGE2, TNF-α, and IL-6 after IL-1β stimulation is inhibited by LIG at the gene level, whereas COX-2 and iNOS are inhibited at both the gene and protein levels.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study

et al. 2018

Cell Physiol Biochem

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Background/Aims: Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment closely linked to extracellular matrix (ECM) degradation. Ligustilide (LIG) is a major component of the herb Radix Angelicae Sinensis, with demonstrated anti-inflammatory effects. To confirm whether LIG has an equally inhibitory effect on inflammation in human osteoarthritis chondrocytes, we performed in vivo and in vitro experiments to validate the above conjectures and determine the relevant mechanisms. Methods: Quantitative realtime PCR and western blotting were performed to evaluate the expression of MMP-3, MMP-13, ADAMTS-5, iNOS, and COX-2 at both gene and protein levels. An enzyme-linked immunosorbent assay was used to evaluate the levels of other inflammatory factors (PGE2, TNF-α, and IL-6). The PI3K/AKT and nuclear factor kappa B (NF-κB) signaling pathways were also analyzed by western blotting, whereas immunofluorescence was used to assess the expression of collagen II and aggrecan. The in vitro effect of LIG was evaluated by intraperitoneal injection into a mouse osteoarthritis model induced by destabilization of the medial meniscus. Results: LIG lowered the phosphorylation levels of p65, IκBα, and IKKα/β and suppressed the IL-1β-induced expression of MMP-3, ADAMTS-5, iNOS, and COX-2 and the inflammatory factors PGE2, TNF-α, and IL-6. LIG markedly decreased IL-1β-induced degradation of collagen II and aggrecan. In vivo results showed that LIG-treated mouse cartilage showed less damage than the control group; the Osteoarthritis Research Society International (OARSI) score was also lower. LIG further reduced the thickness of the subchondral bone plate and alleviated the synovitis. Conclusion: LIG may act as a promising therapeutic agent for osteoarthritis by attenuating IL-1β-induced inflammation in chondrocytes and ECM degradation via suppression of NF-κB activation by the PI3K/AKT pathway.

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Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice

Cited by 81 publications

References 43 publications

Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice

Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice

Association between body composition and osteoarthritis: A systematic review and meta‐analysis

The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study

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