Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis

Abstract

BB exhibited protection against AMP-induced nasal responsiveness during the grass pollen season in sensitized patients. This is turn may explain its potential clinical efficacy in patients with SAR.

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects

“…Adult studies showed butterbur proved efficacious compared with placebo in sustaining nasal inspiratory flow while being challenged with a potent nasal congestant, adenosine monophosphate, 93 and when compared with fexofenadine, it provided equally significant effective relief from intermittent allergic rhinitis both by subjective patient ratings and by the physician's global assessment. 94 Urtica dioica is a plant whose leaf, flower, seed, and root each contain different chemical constituents, including histamine, thus the common name stinging nettle.…”

Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine‐controlled study of Butterbur extract Ze 339

“…The pyrrolizidine alkaloids of the plant are toxic, thus the reliable removal of these compounds is essential for therapeutic use of extracts. Butterbur has been shown to inhibit the biosynthesis of leukotrienes associated with spasmolytic activity and type-I hypersensitivity (Brune et al, 1993;Bickel et al, 1994;Thomet et al, 2001;Meier and Meier-Liebi, 1994;Schapowal et al, 2004), and has been evaluated to treat asthma and particularly allergic rhinitis (Schapowal et al, 2002(Schapowal et al, , 2004Lee et al, 2003;Jackson et al, 2004aJackson et al, , 2004b.…”

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

“…The efficacy of butterbur in persistent allergic rhinitis has yet to be determined. In a small clinical study of twenty patients with grass-pollen-sensitized allergic rhinitis, butterbur was effective at reducing adenosine monophosphate-induced nasal responsiveness during the grass pollen season [59].…”