Butterbur extract: Prophylactic treatment for childhood migraines

Objective: Zinc oxide eugenol (ZOE) is one of the most commonly used root canal sealer. However, it has few drawbacks such as cytotoxicity, solubility, and irritation to periapical tissues. The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with the modification of its liquid component by the addition of petasin extract in the ratios 1:1, 5:1, and 10:1. Materials and Methods: Setting time was evaluated using the Vicat's apparatus. For testing solubility, the American Dental Association's specification #8 was adopted with certain modifications. Protein denaturation assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay with L929 mouse fibroblast cell lines were used to evaluate the anti-inflammatory property and cytotoxicity, respectively. Results: ZOE sealer with petasin extract in the ratio of 5:1 showed the least initial and the final setting times. There was no statistically significant difference in the amount of solubility for all the groups at the various time intervals. The cytotoxicity of the control group was significantly greater than all the experimental groups, whereas the anti-inflammatory effect of the former was statistically lower. Conclusions: The combination of ZOE with petasin extract in the ratio of 5:1 showed lower setting time, cytotoxicity, and better anti-inflammatory property.

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“…[ 10 11 12 13 ] Petasin has been evidenced to have a range of anti-inflammatory and analgesic properties. [ 14 15 ]…”

Section: Discussionmentioning

confidence: 99%

A novel petasin-modified zinc oxide eugenol sealer

2019

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“…Neurasites ® (derived from a genus of flowering plants in the sunflower family, Asteraceae, commonly referred to as butterbur)—150 mg with a minimum of 7.5% sesquiterpene (S-petasin, which supports the normal functioning of blood vessels)—acts to inhibit vasodilation and cyclooxygenase so as to reduce the duration of migraine attacks. The frequency of the attacks is reduced through the regulating effect on calcium channels and by inhibiting the synthesis of leukotri, thus resulting in a decrease in the intensity of pain [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…2024, 13, x FOR PEER REVIEW 4 of (S-petasin, which supports the normal functioning of blood vessels)-acts to inhibit vasodil tion and cyclooxygenase so as to reduce the duration of migraine attacks. The frequency of th attacks is reduced through the regulating effect on calcium channels and by inhibiting th synthesis of leukotri, thus resulting in a decrease in the intensity of pain [29].…”

Section: Methodsmentioning

confidence: 99%

Neurasites®—A Standardized Plant Extract in the Treatment and Prevention of Migraine Attacks

Lunguț,

Antal,

Turcu

et al. 2024

JCM

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Background/Objectives: Migraine is one of the most common diseases in highly developed countries, being even more common than diabetes and asthma. Migraines can affect emotional, social, and physical wellbeing as well as professional life. The most common symptoms are severe headaches associated with nausea, vomiting, photophobia and sonophobia, difficulty concentrating, sensitivity and emotional disorders. Many studies have been published to establish the best migraine-management drugs, but not many of them refer to plant extracts, which have been given more attention by patients lately. Among these generically called herbal medicines, the effect of tussilago hybrida standardized extract has been studied since the early twenties. This stands as the fundamental component of Neurasites® and the reason for research on materials and methods, results on treatment schemes for diminishing migraine attack features, as well as migraine prevention. Methods: There are two directions of research (herbal and placebo medicine) considered to be of interest due to the actual trend toward natural medicine and against chemicals and associated drugs. For quantitative research, the research tool used was that of the Neurasites® Questionnaire Survey (NQS). Results: The obtained results prove the efficacy of treatment by reducing the duration of headache attacks, diminishing pain intensity and decreasing the frequency of migraine episodes. Conclusions: Further research development should focus on other dosages and treatment schemes and on other similar natural products to be used in migraine attack treatment.

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“…(butterbur) (Benemei et al, 2017). Butterbur, as one type of nutraceuticals in preventive therapy, had been verified clinical effectiveness in pediatric migraine (Utterback, Zacharias, Timraz, & Mershman, 2014). Although Petadolex as a standardized butterbur root extract showed positive efficacy for the treatment of migraine in adults, herbal co‐medication was often accompanied by potential liver injury (N. Anderson & Borlak, 2019).…”

Section: Othersmentioning

confidence: 99%

Role of herbal medicine for prevention and treatment of migraine

Chen

Wang

2021

Phytotherapy Research

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Migraine is a disabling neurovascular disease with unilateral or bilateral pulsatile headache, which intensively affects human health and quality of life due to high morbidity worldwide. Migraine is commonly accompanied by abnormal pain sensitization, neuroinflammatory response, and vasomotor dysfunction. Owing to the management dilemmas of migraine, there is an urgent need to develop effective and low-cost therapies. In recent years, herbal medicines as a promising strategy with analgesic activity and minor side effect, have been proposed for the prevention and treatment of migraine. Considering the lack of a review integrating experimental studies regarding the herbal treatment of migraine, this review systematically summarizes the important potential applications of herbal medicines in ameliorating migraine via multiple therapeutic targets and pathways, as well as provides a reference for further development of novel antimigraine drugs.

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Butterbur extract: Prophylactic treatment for childhood migraines

Cited by 8 publications

References 22 publications

A novel petasin-modified zinc oxide eugenol sealer

A novel petasin-modified zinc oxide eugenol sealer

Neurasites®—A Standardized Plant Extract in the Treatment and Prevention of Migraine Attacks

Role of herbal medicine for prevention and treatment of migraine

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