Butyrate dietary supplementation promotes tolerant responses in a Pru p 3‐anaphylactic mouse model

Cruz‐Amaya, Anyith; Martín‐Astorga, María del Carmen; Lebrón‐Martín, Clara; Paris, Juan Luis; Céspedes, José Antonio; Núñez, Rafael; Torres, María José; Aranda, Carlos José; Cañas, José Antonio; Mayorga, Cristobalina

doi:10.1111/all.16033

Allergy

2024

DOI: 10.1111/all.16033

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Butyrate dietary supplementation promotes tolerant responses in a Pru p 3‐anaphylactic mouse model

Anyith Cruz‐Amaya,

María del Carmen Martín‐Astorga,

Clara Lebrón‐Martín

et al.

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2024

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Cited by 1 publication

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Dietary fiber pectin alters the gut microbiota and diminishes the inflammatory immune responses in an experimental peach allergy mouse model

Steigerwald,

Albrecht,

Blissenbach

et al. 2024

Sci Rep

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Since therapeutic options are limited the utilization of prebiotics is suggested to prevent food allergies (FAs). Using an experimental peach allergy model we explored the effect of dietary fiber pectin, a high-methoxyl heteropolysaccharide, on the manifestation of FA. CBA/J mice were sensitized, subsequently orally boosted and provoked with peach peel extract. For dietary intervention, mice were fed a pectin containing diet before (primary-preventive) or after (secondary-preventive) sensitization. Non-treated allergic and sham-treated mice were fed a diet containing 20% cellulose. Fecal microbiota, humoral and intestinal immune cell responses were analyzed. Pectin remarkably affected the gut microbiota composition and diversity, promoting mainly the growth of Bacteroides. The frequency of mast cells, macrophages, and CD3+T cells in the lamina propria of the small intestine was reduced, whereas the frequency of B cells and CD4+T cell subpopulation was enhanced. Pectin intervention in the primary-preventive stetting significantly triggered serum IgA levels, whereas production of IgE and mMCPT-1 was reduced. Remarkably, in both settings peach allergen-specific IgG1/IgG2a ratio and specific IgE were significantly reduced to baseline. The data suggest, that dietary supplementation of pectin in both intervention approaches can diminish inflammatory responses and signs of allergic immune responses, accompanied by alteration of the gut microbiota composition.

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Dietary fiber pectin alters the gut microbiota and diminishes the inflammatory immune responses in an experimental peach allergy mouse model

Steigerwald,

Albrecht,

Blissenbach

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Butyrate dietary supplementation promotes tolerant responses in a Pru p 3‐anaphylactic mouse model

Cited by 1 publication

References 8 publications

Dietary fiber pectin alters the gut microbiota and diminishes the inflammatory immune responses in an experimental peach allergy mouse model

Dietary fiber pectin alters the gut microbiota and diminishes the inflammatory immune responses in an experimental peach allergy mouse model

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