Butyrate’s (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer

Karim, Md. Rezaul; Iqbal, Safia; Mohammad, Shahnawaz; Morshed, Md. Niaj; Haque, Md. Anwarul; Mathiyalagan, Ramya; Yang, Deok Chun; Kim, Yeon Ju; Song, Joong Hyun; Yang, Dong Uk

doi:10.1007/s00203-024-03834-7

Cited by 9 publications

(1 citation statement)

References 115 publications

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“…As its abundance increases, the consumption of acetate also increases. Eubacteria are associated with the production of VFA in the gastrointestinal tract, especially propionate and butyrate, which can convert monosaccharides into butyrate [ 71 , 72 ]. In our study, the increase in the relative abundance of Endomicrobium , Eubacteria ruminantium_group , and Eubacteria Venturiosum_group in the COS group accurately explained the increase in butyrate content, while the decrease in acetate content may be due to the decrease in the relative abundance of Acetobacter and Subdoligranum , as well as the increase in the abundance of Halomonas , which has a greater impact on acetate production than Endomicrobium .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Chito-Oligosaccharides on Disappearance Rate of Nutrients, Rumen Fermentation Parameters, and Micro-Flora of Beef Cattle

He,

Li,

Gao

et al. 2024

Animals

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The study aimed to investigate the effect of dietary chitosan oligosaccharides (COS) meal levels on the nutrient disappearance rate, rumen fermentation, and microflora of beef cattle in vitro. A total of 24 fermentation tanks were randomly divided into four treatments containing 0% COS (CON), 0.02% COS, 0.04% COS, and 0.08% COS for an 8-day experiment period, with each treatment comprising six replicates. The disappear rates of DM, CP, EE, and total gas production were quadratically increased with increasing COS levels. The disappear rates of DM, CP, EE, and ADF were greatest, whereas the total gas production was lowest in the 0.08% COS group. The pH, NH3-N, MCP, the content of propionate, isobutyrate, butyrate, valerate, and the A/P were quadratically increased with increasing COS levels, while the A/P were linearly decreased. The pH, MCP, and the content of propionate, and butyrate were highest, whereas the NH3-N and the content of acetate, isobutyrate, valerate, and the A/P were lowest in the 0.08% COS group. Microbiomics analysis showed that the rumen microbial diversity was not altered between the CON and the 0.08% COS group. However, the relative abundance of Methanosphaera, Ruminococcus, Endomicrobium, and Eubacterium groups was increased, and the relative abundance of pathogenic bacteria Dorea and Escherichia-Shigella showed a decrease in the 0.08% COS group. Overall, the 0.08% COS was the most effective among the three addition levels, resulting in an increase in the disappearance rate of in vitro fermented nutrients and improvements in rumen fermentation indexes and microbial communities. This, in turn, led to the maintenance of rumen health.

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Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Chito-Oligosaccharides on Disappearance Rate of Nutrients, Rumen Fermentation Parameters, and Micro-Flora of Beef Cattle

He,

Li,

Gao

et al. 2024

Animals

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Influence of gut and lung dysbiosis on lung cancer progression and their modulation as promising therapeutic targets: a comprehensive review

Thapa,

Magar,

Shrestha

et al. 2024

MedComm

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Lung cancer (LC) continues to pose the highest mortality and exhibits a common prevalence among all types of cancer. The genetic interaction between human eukaryotes and microbial cells plays a vital role in orchestrating every physiological activity of the host. The dynamic crosstalk between gut and lung microbiomes and the gut–lung axis communication network has been widely accepted as promising factors influencing LC progression. The advent of the 16s rDNA sequencing technique has opened new horizons for elucidating the lung microbiome and its potential pathophysiological role in LC and other infectious lung diseases using a molecular approach. Numerous studies have reported the direct involvement of the host microbiome in lung tumorigenesis processes and their impact on current treatment strategies such as radiotherapy, chemotherapy, or immunotherapy. The genetic and metabolomic cross‐interaction, microbiome‐dependent host immune modulation, and the close association between microbiota composition and treatment outcomes strongly suggest that designing microbiome‐based treatment strategies and investigating new molecules targeting the common holobiome could offer potential alternatives to develop effective therapeutic principles for LC treatment. This review aims to highlight the interaction between the host and microbiome in LC progression and the possibility of manipulating altered microbiome ecology as therapeutic targets.

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The Protective Potential of Butyrate against Colon Cancer Cell Migration and Invasion Is Critically Dependent on Cell Type

Oncel,

Safratowich,

Zeng

2024

Molecular Nutrition Food Res

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ScopeShort‐chain fatty acids such as butyrate are produced through the fermentation of dietary fiber by colonic bacteria. Preclinical studies indicate an anticancer potential of butyrate, but clinical evidence shows greater variability. The study hypothesizes the effectiveness of butyrate on reducing colon cancer cell migration and invasion may vary due to the cell‐type.Methods and resultsThe study determines the efficacy of butyrate (0–4 mM) to inhibit cancer cell migration, invasion, and related signaling proteins in three distinct human colorectal cancer (CRC) cell lines: HCT116, HT‐29, and Caco‐2. Butyrate exhibits a dose‐dependent inhibitory effect on cancer cell migration and invasion. This inhibitory potential on oncogenic focal adhesion kinase (FAK) and sarcoma (Src) proteins is greater in HCT116 cells (1.1 and 0.8‐fold) and HT‐29 cells (0.9 and 0.4‐fold) compared to Caco‐2 cells, respectively. Conversely, E‐cadherin protein, a classical epithelial cell marker and potential tumor suppressor, is 2.3‐fold greater in HCT116 cells than in HT‐29 cells and Caco‐2 cells. Moreover, survival analysis from a public cancer database demonstrates that CRC patients with high E‐cadherin expression have a 13% greater 5‐year survival rate than those with low expression.ConclusionCollectively, butyrate's anti‐cancer efficacy on CRC cells varies depending on cell‐type and is linked to the FAK/Src/E‐cadherin pathway.

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Butyrate’s (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer

Cited by 9 publications

References 115 publications

In Vitro Evaluation of Chito-Oligosaccharides on Disappearance Rate of Nutrients, Rumen Fermentation Parameters, and Micro-Flora of Beef Cattle

In Vitro Evaluation of Chito-Oligosaccharides on Disappearance Rate of Nutrients, Rumen Fermentation Parameters, and Micro-Flora of Beef Cattle

Influence of gut and lung dysbiosis on lung cancer progression and their modulation as promising therapeutic targets: a comprehensive review

The Protective Potential of Butyrate against Colon Cancer Cell Migration and Invasion Is Critically Dependent on Cell Type

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