Butyric acid glycerides in the diet of broilers to replace conventional growth promoters: effects on performance, metabolism, and intestinal health

Ficagna, Cassio Antônio; Galli, Gabriela M.; Zatti, Emerson; Sponchiado, Bruno; Cécere, Bruno Giorgio de Oliveira; Deolindo, Guilherme Luiz; Tarasconi, Lara; Horn, Vitor Waldir; Mendes, Ricardo E.; Bissacotti, Bianca Fagan; Schetinger, Maria Rosa Chitolina; Boiago, Marcel Manente; Silva, Aleksandro S. Da

doi:10.1080/1745039x.2022.2162796

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Sodium butyrate can enhance intestinal morphology, promote the differentiation of intestinal epithelial cells, maintain the balance of intestinal microbiota, inhibit the growth of harmful bacteria, and increase the proliferation of beneficial bacteria ( Liu et al, 2020 ; El-Saadony et al, 2022 ; Kaźmierczak-Siedlecka et al, 2022 ). Consequently, it augments the digestion and absorption rates of nutrients, effectively improving the growth performance of animals ( Ficagna et al, 2022 ). However, the foul odor and irritating taste of sodium butyrate not only have a negative impact on animal intake, but also readily absorb moisture when exposed to air, leading to significant detrimental effects on feed production and storage, ultimately severely compromising animal palatability ( Le Gall et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

Hou,

Lu,

Lian

et al. 2024

Front. Microbiol.

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IntroductionThis study examined the impact of adding coated sodium butyrate (CSB) to the diet on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and cecal microbiota of yellow-feathered broiler chickens.MethodsIn this study, 240 yellow-feathered broiler chickens at 26 days old were divided into two groups: the control group (CON group) received a standard diet, and the experimental group (CSB group) received a diet with 0.5 g/kg of a supplement called CSB. Each group had 6 replicates, with 20 chickens in each replicate, and the experiment lasted for 36 days.ResultsCompared to the CON group, the CSB group showed a slight but insignificant increase in average daily weight gain during the 26–62 day period, while feed intake significantly decreased. The CSB group exhibited significant increases in serum superoxide dismutase, catalase, and total antioxidant capacity. Additionally, the CSB group had significant increases in total protein and albumin content, as well as a significant decrease in blood ammonia levels. Compared to the CON group, the CSB group had significantly increased small intestine villus height and significantly decreased jejunal crypt depth. The abundance of Bacteroidetes and Bacteroides in the cecal microbiota of the CSB group was significantly higher than that of the CON group, while the abundance of Proteobacteria, Deferribacteres, and Epsilonbacteraeota was significantly lower than that of the CON group.ConclusionThese results suggest that adding CSB to the diet can improve the growth performance and antioxidant capacity of yellow-feathered broiler chickens while maintaining intestinal health.

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Section: Introductionmentioning

confidence: 99%

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

Hou,

Lu,

Lian

et al. 2024

Front. Microbiol.

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“…As one of the growth promoters and immune function regulators in the field of animal nutrition, sodium butyrate (SB) has attracted global interest [4,5]. Butyrate acts as a key short-chain fatty acid in the gut and serves as primary fuel for the metabolism of colonocytes, while also improving the integrity of epithelial tissue, alleviating the inflammation of mucosa, and stimulating the absorption of electrolytes [6,7].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Microcapsule Sustained-Release Sodium Butyrate on the Growth Performance, Immunity, and Gut Microbiota of Yellow Broilers

Dai,

Wang,

Liu

et al. 2023

Animals

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The beneficial effects of butyric acid in poultry production are well documented, while the relationship between sodium butyrate (SB) and microcapsule sustained-release sodium butyrate (MSSB), especially in yellow broilers, remains poorly investigated. This study was designed to elucidate the function as well as the potential mechanisms of SB and MSSB in enhancing health in yellow broilers. In total, 360 one-day-old yellow broilers were allocated to three treatment groups. The control group (CON) received a basic diet, while the SB group was provided with 1000 mg/kg of sodium butyrate (SB), and the MSSB received microcapsule sustained-release sodium butyrate (MSSB), all over a period of 56 days. Compared to the CON group, the dietary supplementation of both SB and MSSB showed a lower feed:gain ratio (p < 0.01). No significant (p > 0.05) difference in antioxidant capacity was observed between the three groups. We observed significantly higher levels (p < 0.05) of immunoglobulins and a reduction in concentrations in both the SB and MSSB groups compared to the CON group. Furthermore, both SB and MSSB induced alterations in the diversity, structure, and function of gut microbiota. MSSB demonstrated even more pronounced beneficial effects than SB, particularly in regard to the serum IgA level (p = 0.05), cecal isovalerate concentration (p < 0.05), and villus height (p < 0.01). The sequencing of the gut microbiota revealed that MSSB led to a significant increase in the relative abundance of Clostridia UCG-014, Bacilli RF39, and Oscillospiraceae UCG-005. Predictions of bacterial function indicated changes in KEGG pathways, including an enrichment of tryptophan metabolism (ko00380), and a reduction in fructose and mannose metabolism (ko00051), chloroalkane and chloroalkene degradation (ko00625), and naphthalene degradation (ko00626) in yellow broilers fed with MSSB. Among these, the mediation analysis revealed a causal effect between the Clostridia UCG-014 in the gut and serum IgA, with tryptophan metabolism being a key mediator in this relationship. Our results suggest that dietary MSSB can improve the growth performance, immunity, and gut microbiota of yellow broilers. MSSB increased the abundance of Clostridia UCG-014 and activated the tryptophan metabolism pathway (ko00380), contributing to IgA levels in yellow broilers through this mechanism.

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Organic acids in poultry industry: a review of nutritional advancements and health benefits

Du,

Sarwar,

Ahmad

et al. 2023

World's Poultry Science Journal

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Butyric acid glycerides in the diet of broilers to replace conventional growth promoters: effects on performance, metabolism, and intestinal health

Cited by 5 publications

References 35 publications

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

Effects of Dietary Microcapsule Sustained-Release Sodium Butyrate on the Growth Performance, Immunity, and Gut Microbiota of Yellow Broilers

Organic acids in poultry industry: a review of nutritional advancements and health benefits

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