Butyricimonas faecihominis and Eubacterium callanderi mixed bloodstream infection after appendicular peritonitis

Kamel, Omar Farouk; Noten, Héloïse Van; Argudín, Maria Ángeles; Martiny, Delphine

doi:10.1016/j.anaerobe.2021.102419

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…Our research findings are consistent with previous studies, suggesting a favorable causal relationship between Lachnospiraceae UCG004 genus and Lachnospiraceae FCS020 genus and sepsis and its survival outcomes, while Lachnospiraceae ND3007 genus showed unfavorable effects. Eubacterium genus bacteria have been shown to play critical roles in various aspects, including bile acid and cholesterol transformation, involvement in oxalate metabolism, promotion of anti-inflammatory molecule production, prevention of allergic airway inflammation, modulation of insulin secretion, and regulation of lipid metabolism [ 61 , 62 ]. Ruminococcus is a common genus of gut bacteria that plays a significant role in the digestion and metabolism of resistant starch.…”

Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Yang,

Guo,

Kong

et al. 2024

J Transl Med

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Background Gut microbiota alterations have been implicated in sepsis and related infectious diseases, but the causal relationship and underlying mechanisms remain unclear. Methods We evaluated the association between gut microbiota composition and sepsis using two-sample Mendelian randomization (MR) analysis based on published genome-wide association study (GWAS) summary statistics. Sensitivity analyses were conducted to validate the robustness of the results. Reverse MR analysis and integration of GWAS and expression quantitative trait loci (eQTL) data were performed to identify potential genes and therapeutic targets. Results Our analysis identified 11 causal bacterial taxa associated with sepsis, with increased abundance of six taxa showing positive causal relationships. Ten taxa had causal effects on the 28-day survival outcome of septic patients, with increased abundance of six taxa showing positive associations. Sensitivity analyses confirmed the robustness of these associations. Reverse MR analysis did not provide evidence of reverse causality. Integration of GWAS and eQTL data revealed 76 genes passing the summary data-based Mendelian randomization (SMR) test. Differential expression of these genes was observed between sepsis patients and healthy individuals. These genes represent potential therapeutic targets for sepsis. Molecular docking analysis predicted potential drug-target interactions, further supporting their therapeutic potential. Conclusion Our study provides insights for the development of personalized treatment strategies for sepsis and offers preliminary candidate targets and drugs for future drug development.

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Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Yang,

Guo,

Kong

et al. 2024

J Transl Med

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“…This case underscores the clinical challenges posed by the presence of a rare pathogen, such as Butyricimonas faecihominis . This recently discovered species has been isolated from human faeces [ 5 , 6 ] and has been described as a cause of bloodstream infection [ 7 ]. This is also in accordance with our assessment of Butyricimonas faecihominis being the potential causative agent for the described case: Pathogens cultivated from abscesses are part of the respective physiological flora [ 8 ], hence – in our case - the gastrointestinal microbiota.…”

Section: Discussionmentioning

confidence: 99%

Butyricimonas faecihominis: an atypically resistant bacterium implicated in abscess formation - a case report

Wessendorf,

Brezina,

Dusse

et al. 2024

BMC Infect Dis

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Background This case report presents a unique instance of abscesses with an uncommon pathogen isolated from blood cultures. Case presentation We present the case of a perianal abscess in a 50-year-old man with a history of cocaine abuse and bilateral hip replacements. The rapid progression led to septic shock and multi-organ failure, requiring intensive care unit admission, surgery including protective transversostomy. Blood cultures showed growth of Butyricimonas spp. with resistance to penicillin and piperacillin-tazobactam. The immediate switch to meropenem led to a significant improvement in the patient’s condition. The patient was discharged after 40 days of hospitalization in good general condition and the reversal of the transversostomy was performed six months later. Conclusion The identification of Butyricimonas faecihominis, a rarely reported pathogen, emphasizes the challenges of diagnosing and treating unusual infections. This case emphasizes the importance of rapid microbiological diagnosis, interdisciplinary collaboration, and targeted antibiotic therapy in the treatment of abscesses and sepsis.

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Butyricimonas paravirosa bacteremia associated with acute terminal ileitis: Case report and literature review

Whitehill,

Zhuo,

Yang

2024

Anaerobe

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Butyricimonas faecihominis and Eubacterium callanderi mixed bloodstream infection after appendicular peritonitis

Cited by 6 publications

References 20 publications

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Butyricimonas faecihominis: an atypically resistant bacterium implicated in abscess formation - a case report

Butyricimonas paravirosa bacteremia associated with acute terminal ileitis: Case report and literature review

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