Butyrylcholinesterase Activity and Pregnancy‐Associated Differences in Immunologically Relevant Peripheral Blood Leukocyte Populations

Abstract

Elevated BuChE activity in normal pregnancy may correlate with better ability to clear pregnancy-threatening toxins, while lesser ability to do this in PIH women may be a contributor to disease. The fact that PIH subjects with large subpopulations of activated T cells also exhibited low BuChE activity further suggests a correlation between susceptibility to pregnancy loss and decreased activity of the enzyme.

Variant K of butyrylcholinesterase and risk of early‐onset type 1 diabetes mellitus in Euro‐Brazilians

“…Association of the K variant (1615nt: GCA→ACA; Ala539Thr) of this gene with type 2 diabetes mellitus was reported in one study [1] and not confirmed by another [2]. Considering that the K variant is associated with 30% reduction in BChE activity [3] and that low BChE activity was related to immune dysfunction [4], the hypothesis that this variant may be positively associated with type 1 diabetes mellitus (DM1) was tested.…”

“…The present data suggest that the K variant or another variant in linkage disequilibrium with it may predispose to DM1 of earlier onset. The facts that BChE is a biological scavenger for organophosphorus compounds [7] that may provoke immune dysfunction [8] and that low BChE activity may be related to immune dysfunction [4] may be the rationale for the association found between the K variant and DM1 of relatively earlier onset.…”

Pseudocholinesterase in gestational diabetes: positive correlation with LDL and negative correlation with triglyceride

“…Furthermore, as all patients had normal liver and renal functions, this could explain the normal enzyme levels and BMI. Mahmoud et al [10,11] reported that there was evidence that Kuwaiti women experiencing pregnancy disorders, such as pre-eclampsia and diabetes during their pregnancies had lower serum activity of BChE; however, the mechanisms involved in GD have not been fully investigated. Whiteman et al [12] reported that interpregnancy weight gain is associated with a doseresponse increase in the risk of diabetes.…”

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives

“…Additionally, the magnitude of the reduction of AChE expression is proportionally related to PE severity [33]. Alternatively, levels and activity of BChE in maternal circulation as well as in fetal umbilical cord blood have been repeatedly shown to be diminished in PE compared with healthy pregnancy [112][113][114][115][116]. Similar decreases in cholinesterase activity have been documented in severe trauma and sepsis [117,118].…”