By-products of dates, cherries, plums and artichokes: A source of valuable bioactive compounds

Mateus, Ana; Pena, Angelina; Sendón, Raquel; Almeida, Carina; Almeida, Gonçalo; Khwaldia, Khaoula; Sanches-Silva, A.

doi:10.1016/j.tifs.2022.12.004

Cited by 44 publications

(30 citation statements)

References 136 publications

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“…As it was previously demonstrated, artichoke leaf extracts have also shown choleretic, hepatoprotective, bile-enhancing, antimicrobial, hypocholesterolemic, hypoglycemic, and anticancer effects both in vitro and in vivo research [ 5 , 55 , 56 , 57 , 58 , 59 ].…”

Section: Inflammatory and Gastrointestinal Diseases And Artichokementioning

confidence: 98%

“…Research consistently demonstrates that CLA, through reducing oxidative stress, plays a critical role in enhancing the well-being associated with artichoke consumption. Even cynarin, one of the most important members of this class, is well-known for having possible hepatoprotective effects [ 5 ]. As a result, research on its role in promoting liver health has been conducted, making it a focal point in the exploration of benefits of artichoke consumption.…”

Section: Bioactive Compounds Extracted From C Scolymusmentioning

confidence: 99%

“…Consequently, utilizing by-products from the non-dietary components can be considered as a valuable source of bioactive molecules, including flavonoids, polyphenols, and others, which can contribute to the treatment of chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative pathologies [ 5 ]. This review underscores that C. scolymus waste stands out as a compelling ingredient with therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

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Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects. In this context, preventive approaches are gaining increased attention. Recent literature indicates that the consumption of bioactive compounds in the diet can positively influence the organism’s biological functions. Polyphenols, well-known for their health benefits, are widely recognized as valuable compounds in preventing/combating various pathologies related to lifestyle, metabolism, and aging. The C. scolymus belonging to the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Although the inflorescences (capitula) of the artichoke are used for food and culinary purposes, preparations based on artichoke leaves can be used as an active ingredient in herbal medicines. Cynara scolymus shows potential benefits in different domains. Its nutritional value and health benefits make it a promising candidate for improving overall well-being. C. scolymus exhibits anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering neuroprotective properties. Different studies demonstrate that oxidative stress is the leading cause of the onset and progression of major human health disorders such as cardiovascular, neurological, metabolic, and cancer diseases. The large amount of polyphenol found in C. scolymus has an antioxidant activity, enabling it to neutralize free radicals, preventing cellular damage. This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties. As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies. The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.

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Section: Inflammatory and Gastrointestinal Diseases And Artichokementioning

confidence: 98%

Section: Bioactive Compounds Extracted From C Scolymusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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“…Food wastes and by-products represent a source of high-value-added compounds, such as proteins, fiber, oligosaccharides, fatty acids, lipids, polyphenols, food-grade pigments, and terpenes, that could be exploited in different industrial sectors [93][94][95]. These compounds are naturally present in edible and non-edible parts, and the second part often contains higher amounts of bioactive compounds, such as fiber and oligosaccharides, when compared to the edible parts [96].…”

Section: Social Impactsmentioning

confidence: 99%

From Industrial Food Waste to Bioactive Ingredients: A Review on the Sustainable Management and Transformation of Plant-Derived Food Waste

Jaouhari,

Travaglia,

Giovannelli

et al. 2023

Foods

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According to the United Nations, approximately one-third of the food produced for human consumption is wasted. The actual linear “Take-Make-Dispose” model is nowadays obsolete and uneconomical for societies and the environment, while circular thinking in production systems and its effective adoption offers new opportunities and benefits. Following the “Waste Framework Directive” (2008/98/CE), the European Green Deal, and the actual Circular Economy Action Plan, when prevention is not possible, recovering an unavoidable food waste as a by-product represents a most promising pathway. Using last year’s by-products, which are rich in nutrients and bioactive compounds, such as dietary fiber, polyphenols, and peptides, offer a wake-up call to the nutraceutical and cosmetic industry to invest and develop value-added products generated from food waste ingredients.

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“…36 Its antioxidant, scavenging of ROS, anti-inflammatory and medicinal activities have been attributed to several phytochemical metabolites including polyphenols, cynarin; mono-and dicaffeoylquinic(1,3-di-O-caffeoylquinic acid), and chlorogenic acid, flavonoids such as luteolin or its glycosides, ferulic acid saponins, inulin, hydroxyl cinnamates-caffeoyl quinic acid derivatives, sesquiterpenes (grosheimin, cyanoropicrin), and fatty acids. 36,37 Moreover, artichokes contain respective amounts of vitamins B complex (biotin, niacin, and pyridoxine), vitamin C, folates, carotenoids, and high levels of some essential elements, such as Na + , K+, manganese (Mn 2+ ), magnesium (Mg 2+ ), zinc (Zn 2 ), and iron (Fe 3+ ). 38,39 The Wnt/β-catenin signaling pathway plays a great consequence role in the health and disease of different organs.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma‐irradiation‐induced chronic nephrotoxicity in rats

Eassawy,

Ismail

2023

Environmental Toxicology

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The prevalence of chronic kidney disease (CKD) is in progress that causes kidney failure, leading to global problems. This manuscript investigated the nephroprotective effects of chicory (CLE) and/or artichoke (ALE) leaves extracts on carbon tetrachloride (CCl4) and gamma‐irradiation (Rad)‐induced chronic nephrotoxicity in rats. Rats were divided into 10 groups (10 animals/group): group 1: control, groups 2–7 rats were treated with CLE, ALE, CLE/ALE, CCl4, Rad, and CCl4/Rad, respectively. Groups 8 to 10, rats were intoxicated with CCl4/Rad, and treated with CLE, ALE, and CLE/ALE extracts, respectively, for 4 weeks. The data demonstrated that CCl4 administration or Rad exposure induced high levels of urea and creatinine, with low levels of total protein and albumin in the serum. However, high levels of malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2), some pro‐inflammatory markers such as interleukins (IL‐1β, IL‐2, IL‐6), TNF‐α, NF‐κB, the fibrotic marker; TGF‐β1, calcium, and copper, low contents of reduced glutathione (GSH), iron, and zinc, and suppression of the antioxidant enzymes' activity, superoxide dismutase (SOD), and catalase (CAT) were observed. In addition, the Wnt and β‐catenin protein expression ratios were up‐regulated in the kidney tissues of the CCl4, and Rad intoxicated animals. However, the combined treatment CCl4/Rad augmented these measurements. On the other hand, CLE, ALE, and CLE/ALE treatments demonstrated nephroprotection in the kidney tissues of CCl4/Rad intoxicated animals, in the order of CLE/ALE>ALE>CLE by ameliorating the investigated parameters. Kidney tissues' histopathological examinations confirmed these results. In conclusion, CLE and/or ALE demonstrated nephroprotection against CCl4/Rad co‐toxicity mediated by down‐regulation of renal Wnt/β‐catenin protein expressions.

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By-products of dates, cherries, plums and artichokes: A source of valuable bioactive compounds

Cited by 44 publications

References 136 publications

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

From Industrial Food Waste to Bioactive Ingredients: A Review on the Sustainable Management and Transformation of Plant-Derived Food Waste

Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma‐irradiation‐induced chronic nephrotoxicity in rats

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