Cornsilk has been a natural remedy for centuries to treat various medical conditions. Recent
research shows the anti-inflammatory activities of cornsilk extract, which can help relieve pain.
Certain biopeptides are involved in the induction of anti-inflammatory action in the administration of
cornsilk extract. The analgesic activity of cornsilk is due to the presence of tannins and polyphenolic
constituents in Zea mays. Besides maysin, many other factors, such as steroids, flavonoids, volatile
oils, and various phenolic compounds, make cornsilk extract a modern anti-inflammatory and
analgesic drug with minor side effects. In diverse cultures and folk medicines, cornsilk is used for its
diuretic properties, reduction in melanin production properties, and antioxidant, anti-inflammatory,
and analgesic properties. Silver nanoparticles using a combined extract of cornsilk, parsley, and
Arabic gum extract have been reported to reduce inflammation. These effects have been observed in
vivo. This formulation has anti-microbial as well as antioxidant properties. This review article
focuses on the newer aspects of the medicinal value of cornsilk.