Bypass of the Blood-Brain Barrier to Proteins Without Brain Tissue Damage

Levin, Emanuel; Tradatti, C. E.

doi:10.1007/978-3-642-66524-0_5

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Osmotic opening of the BBB by carotid perfusion with hypertonic solutions [ 1 2 ] has been suggested as a possible technique for transiently altering the permeability of the blood-brain interface. Refinement of the perfusion procedure has led to BBB opening without neurological deficit [6,151, and i t has been reported that total cerebral blood flow, oxygen consumption, and glucose utilization are not altered under these conditions [7].…”

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Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Pappius

Savaki

Fieschi

et al. 1979

Annals of Neurology

103

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The effects of osmotic opening of the blood-brain barrier (BBB) on local cerebral glucose utilization (LCGU) were studied in rats with the carbon 14-deoxyglucose method. The BBB was opened to Evans blue dye by unilateral carotid artery perfusion with hypertonic mannitol solution. (14C)-Deoxyglucose was injected 15 minutes or two to three hours later. Osmotic opening of the BBB resulted in focal areas of intense LCGU in affected areas of the perfused hemisphere. In the contralateral hemisphere, glucose utilization was diminished, especially in cerebral cortical areas. The effects were reversible. LCGU was normal in both hemispheres when permeability to Evans blue returned to normal two to three hours after carotid artery perfusion. In 3 of 5 experiments the administration of high doses of intravenous diazepam immediately following carotid artery perfusion with mannitol prevented an increase in LCGU in the perfused hemisphere but did not prevent lowering of LCGU in the contralateral hemisphere. Increased LCGU following osmotic opening of the BBB was not accompanied by a rise in local cerebral blood flow as measured by the iodoantipyrine method. Blood flow was, in fact, significantly decreased.

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mentioning

confidence: 99%

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Pappius

Savaki

Fieschi

et al. 1979

Annals of Neurology

103

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Cerebral Blood Volume and Water Extraction from Cerebral Parenchyma by Hyperosmolar Contrast Media

Caillé¹,

Billerey²,

Renou³

et al. 1978

Proceedings of the XI. Symposium Neuroradiologicum

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Cerebral blood volume and water extraction from cerebral parenchyma by hyperosmolar contrast media

et al. 1978

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The attenuation coefficients of cerebral parenchyma and systemic blood were simultaneously measured at varying times after injection of two contrast agents with differing osmolarities. Cerebral parenchyma was in fact denser than the theory would predict. The osmolarity of the iodinated contrast agents seems to play only a very minor part. However, liposolubility could perhaps explain the leakage of iodine across the BBB and thus the increase in the attenuation coefficient of cerebral parenchyma.

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Bypass of the Blood-Brain Barrier to Proteins Without Brain Tissue Damage

Cited by 4 publications

References 8 publications

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Cerebral Blood Volume and Water Extraction from Cerebral Parenchyma by Hyperosmolar Contrast Media

Cerebral blood volume and water extraction from cerebral parenchyma by hyperosmolar contrast media

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