Byrsonima crassifolia extract and fraction prevent UVB-induced oxidative stress in keratinocytes culture and increase antioxidant activity on skin

Souza, Rebeca Oliveira de; Alves, Geórgia de Assis Dias; Forte, Ana Luiza Scarano Aguillera; Marquele-Oliveira, Franciane; Silva, Daniele Fernandes da; Rogez, Hervé; Fonseca, Maria José Vieira

doi:10.1016/j.indcrop.2017.07.015

Cited by 15 publications

(13 citation statements)

References 46 publications

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“…The O 2 •- scavenging ability of DHCA was lower than the ability of QT in the XOD assay, with a higher IC 50 value. However, DHCA showed similar or even better results than other natural products (DHCA IC 50 0.17 μ g/mL, Byrsonima crassifolia purified extract IC 50 0.23 μ g/mL; Byrsonima crassifolia fraction IC 50 0.10 μ g/mL) [25].…”

Section: Resultsmentioning

confidence: 99%

“…Many studies have demonstrated that fibroblasts in monolayer culture reproduce various forms of UVB-induced photodamage at the cellular level [1, 17]. To prevent damage generated by UVB irradiation and maintain healthy and beautiful skin, several studies have focused on compounds or extracts with antioxidant properties [17, 25]. It has been reported that DHCA exhibits antioxidant activity, which is attributed to catechol structure and carboxyl group found in DHCA [33].…”

Section: Discussionmentioning

confidence: 99%

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Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

Oliveira

Ratti

Daré

et al. 2019

Oxidative Medicine and Cellular Longevity

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Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H2O2) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

Oliveira

Ratti

Daré

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Las ros pueden reaccionar con moléculas orgánicas (proteínas, carbohidratos, ácidos nucleicos y, especialmente, lípidos) y causar pérdida de integridad celular, peroxidación de lípidos y la liberación de citoquinas. Este proceso finalmente causará lesiones en la piel y acelerará el envejecimiento, así como el desarrollo de enfermedades malignas (Peres et al 2011). De Souza et al (2017 llevaron a cabo un estudio con piel de oreja de cerdo y se demostró que el extracto de hojas de nanche tiene una excelente penetración de compuestos fenólicos en la epidermis/dermis, lo que proporcionó un aumento en el potencial antioxidante de la piel.…”

Section: Aplicación De Compuestos Funcionales De Nancheunclassified

Compuestos de interés funcional del nanche (Byrsonima crassifolia (L.) H.B.K.)

Garza

López-Guzmán

Balois-Morales

et al. 2021

aap

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Nance fruit ( Byrsonima crassifolia (L.) H.B.K.) is a product for fresh consumption that provides a high content of bioactive compounds with antioxidant activity, vitamin C, and dietary fiber. In addition, it has been reported that the fruit, leaves, and seeds have antioxidant, antimicrobial, an- ti-inflammatory, antiproliferative, anti-depressive, and antidiabetic properties. The main objective of this research was the collection of information from the last 10 years on the Nance fruit physi- cochemical, nutritional and functional bioactive compounds that are beneficial to health (polyphe- nols, flavonoids, vitamins, anthocyanins, fiber).

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“…O processo de fracionamento proporcionou também um aumento na concentração de compostos fenólicos. Neste ensaio para o efeito fotoquimioprotetor, a concentração máxima de extrato e fração estabelecida quando testada em porcos foi de 5 μg / mL, e a concentração máxima padrão foi de 10 μg / mL 23 .…”

Section: Potencial De Citotoxidadeunclassified

Propriedades farmacológicas de Byrsonima crassifolia (L.) Kunt

Almeida

Maranhão

Vasconcelos

et al. 2019

RIB

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Os medicamentos provenientes de plantas estão presentes há milhares de anos na população. Muitas pessoas fazem uso destes produtos na forma de comprimidos, cápsulas, xaropes ou ainda utilizando a planta seca, inteira ou fracionada principalmente na forma de chás. A espécie Byrsonima crassifolia tem um grande potencial de ação terapêutico e está amplamente distribuída na Amazônia Brasileira, América Central e Caribe, sendo conhecida popularmente no Brasil com o nome de muricizeiro. Diversos registros na literatura abordam suas propriedades farmacêuticas, seja para o tratamento do controle da diabetes, depressão e de quadros inflamatórios. Por observar esta vasta quantidade de usos na literatura e, diante da necessidade de um cuidado maior na utilização de medicamentos provenientes de plantas em virtude de agentes tóxicos, foi realizado um estudo de revisão de literatura sobre as propriedades farmacêuticas e o potencial citotóxico de B. crassifolia. Palavras-chave: Byrsonima crassifolia. Muricizeiro. Propriedades farmacêuticas. Potencial citotóxico.

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Byrsonima crassifolia extract and fraction prevent UVB-induced oxidative stress in keratinocytes culture and increase antioxidant activity on skin

Cited by 15 publications

References 46 publications

Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

Compuestos de interés funcional del nanche (Byrsonima crassifolia (L.) H.B.K.)

Propriedades farmacológicas de Byrsonima crassifolia (L.) Kunt

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