Byrsonima intermedia A. Juss.: Gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models

Santos, R. C. dos; Kushima, Hélio; Rodrigues, Clenilson Martins; Sannomiya, Míriam; Rocha, Lúcia Regina Machado da; Bauab, Taís Maria; Tamashiro, Jorge Yoshio; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2011.12.008

Cited by 44 publications

(31 citation statements)

References 36 publications

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“…The oral administration of a single dose of each extract decreased the gastric lesions induced by indomethacin or piroxicam, hypothermic restraint stress, ethanol, or pylorus ligature, in the same extent that cimetidine, ranitidine, or lansoprazole (57, 58, 60, 61). Interestingly, the extraction step seems to be critical to determine the antiulcer effects of the bioactive compounds; no significant protective effects were observed when plant infusions were used (57, 58).…”

Section: Pacs In the Stomachmentioning

confidence: 85%

“…Proanthocyanidin extracts from medicinal plants including Mangaba ( Hancornia speciosa ) (containing LMW PACs), Curatella americana L. (Dilleneaceae) (containing oligomeric and polymeric PACs), Cecropia glazioui Sneth (Cecropiaceae) (that contains 22% of PACs B2, B3, B5, and C1), and Byrsonima intermedia (containing oligomeric PACs, phenolic acids, and catechin derivatives and flavonoids) have also been evaluated (57–61). The oral administration of a single dose of each extract decreased the gastric lesions induced by indomethacin or piroxicam, hypothermic restraint stress, ethanol, or pylorus ligature, in the same extent that cimetidine, ranitidine, or lansoprazole (57, 58, 60, 61).…”

Section: Pacs In the Stomachmentioning

confidence: 99%

“…Plant extracts decreased the secretion of HCl by gastric parietal cells when administered intraduodenally to pylorus-ligated mice (57, 58, 60, 61). The C. glazioui extract reversed the histamine or bethanechol-induced acid secretion to basal values, indicating it inhibits the proton pump.…”

Section: Pacs In the Stomachmentioning

confidence: 99%

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The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the prevention and nutritional management of non-communicable chronic diseases. It is considered that PACs with a degree of polymerization >3 remain unabsorbed in the gastrointestinal (GI) tract and accumulate in the colonic lumen. Accordingly, the GI tract may be considered as a key organ for the healthy-promoting effects of dietary PACs. PACs form non-specific complexes with salivary proteins in mouth, originating the sensation of astringency, and with dietary proteins, pancreatic enzymes, and nutrient transporters in the intestinal lumen, decreasing the digestion and absorption of carbohydrates, proteins, and lipids. They also exert antimicrobial activities, interfering with cariogenic or ulcerogenic pathogens in the mouth (Streptococcus mutans) and stomach (Helicobacter pylori), respectively. Through their antioxidant and antiinflammatory properties, PACs decrease inflammatory processes in animal model of gastric and colonic inflammation. Interestingly, they exert prebiotic activities, stimulating the growth of Lactobacillus spp. and Bifidobacterium spp. as well as some butyrate-producing bacteria in the colon. Finally, PACs are also metabolized by the gut microbiota, producing metabolites, mainly aromatic acids and valerolactones, which accumulate in the colon and/or are absorbed into the bloodstream. Accordingly, these compounds could display biological activities on the colonic epithelium or in extra-intestinal tissues and, therefore, contribute to part of the beneficial effects of dietary PACs.

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Section: Pacs In the Stomachmentioning

confidence: 85%

Section: Pacs In the Stomachmentioning

confidence: 99%

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The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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“…Chemical and pharmacological data obtained more recently from the Byrsonima genus can justify its use in folk medicine. Anti-inflammatory [6], gastroprotective, antidiarrheal, antimicrobial [7], and antitubercular activities [8], for instance, have been reported. Phytochemical analyses of the genus showed basically phenolic compounds such as quercetin derivatives and proanthocyanidins [9,10].…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and anti-inflammatory activity of the leaves of Byrsonima verbascifolia

et al. 2016

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An ethnopharmacological survey indicates that the genus Byrsonima has some medicinal species that are commonly found in the Brazilian Cerrado and has been used as an anti-inflammatory and for gastroduodenal disorders. The aim of this study was to evaluate the anti-inflammatory and antioxidant activity along with qualitative chemical characterization of the methanolic extract of the leaves of Byrsonima verbascifolia (BvME) obtained by exhaustive percolation. The data from the chemical analyses by liquid chromatography-mass spectrometry led to tentative identification of 42 compounds belonging to proanthocyanidins, galloyl quinic acid derivatives, flavonoids, and triterpene glycoside derivatives. BvME contain flavonoids and show an antioxidative activity. The methanolic extract administered intraperitoneally at doses of 50, 100, or 300 mg/kg showed a significant reduction in paw edema and modulated the neutrophil influx in a mouse model. Furthermore, the anti-edematogenic activity of the extract provided in smaller doses (12.5 and 25 mg/kg) was also demonstrated in a mouse paw edema model. The extract inhibited NO production by macrophages induced by lipopolysaccharide. We presume that the anti-inflammatory effects of BvME are due to a combination of compounds present in B. verbascifolia, including catechins (procyanidins), flavonoids, and triterpene glycosides and that these anti-inflammatory actions should be mediated, at least partly, through the inhibition of NO production. This study supports and validates the ethnopharmacological uses of B. verbascifolia as an anti-inflammatory.

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“…The methanol extract from B. intermedia leaves presented gastroprotective, antimicrobial and antidiarrheal activities, supporting the traditional use to treat gastrointestinal disorders. 6 High antimutagenic effect in the hydroalcoholic leaf extracts from B. intermedia and B. verbascifolia was related, indicating these plant extracts as potential sources of chemopreventive agents. However, the hydroalcoholic extract from B. coccolobifolia leaves showed mutagenic activity, suggesting caution in their use as medicinal plant.…”

Section: Introductionmentioning

confidence: 97%

Electrospray Ionization Mass Spectrometry Fingerprint of the Byrsonima Species

Pereira¹,

Fonseca²,

Bento³

et al. 2015

Revista Virtual De Química

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Extracts of plants presents a large chemical diversity and usually require extensive time for the isolation and characterization of the compounds. Analysis of complex samples by electrospray ionization source coupled to a mass spectrometry (ESI-MS) and tandem mass spectrometry (ESI-MS/MS) has proven to be useful tools for initial screening of these samples. Therefore, it allows identification of known molecules without isolation or use of other auxiliary analytical techniques. In this work, dried extracts of three Byrsonima species were dissolved in methanol, analyzed through direct injection by ESI-MS and each reason mass-to-charge (m/z) of interest was selected to ESI-MS/MS analysis. ESI-MS fingerprint showed a distinction among the chemical constituents in each of the three Byrsonima species and ESI-MS/MS data was used as a tool to help identify the main components of B. coccolobifolia, B. verbascifolia and B. intermedia extracts. More specifically, phenolic acids, proanthocyanidins and flavonoids were detected in the three Byrsonima species studied.

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Byrsonima intermedia A. Juss.: Gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models

Abstract: Byrsonima intermedia leaves present gastroprotective, healing and antidiarrheal activities, supporting previous claims that its traditional use can treat gastrointestinal disorders.

Cited by 44 publications

References 36 publications

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

Chemical composition and anti-inflammatory activity of the leaves of Byrsonima verbascifolia

Electrospray Ionization Mass Spectrometry Fingerprint of the Byrsonima Species

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