BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway

Shi, Zhenfeng; Xiao, Chutan; Lin, Tengceng; Wu, Jieyin; Li, Ké

doi:10.1080/15384101.2021.1909242

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…[27] BZW1, a member of the bZIP transcription factor superfamily, is involved in the progression of multiple tumors. Shi et al [28] found that highly expressed BZW1 can significantly promote the proliferation of prostate cancer cells by regulating the TGF-β1/Smad pathway. Another study [29] showed that BZW1 and BZW2 are expressed in a variety of cancer types, but BZW1 has a more significant clinicopathological value, and its high expression has poor prognosis in lung adenocarcinoma, and its downregulation can inhibit lung adenocarcinoma metastasis.…”

Section: Discussionmentioning

confidence: 99%

BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma

Luo,

Qiao,

et al. 2024

Medicine

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Pancreatic adenocarcinoma is the most common malignant tumor of the digestive system and is called the “king of cancer” because it has been labeled with high malignancy, rapid progression, poor survival, and poor prognosis. Previously, it was reported that the basic leucine zipper and W2 domains 1 (BZW1) is involved in the progression of many tumors. However, its research in digestive system tumors such as pancreatic cancer is rarely studied. To explore potential biomarkers related to survival and prognosis of pancreatic cancer and provide a new targeted therapy for it. We first analyzed the mRNA and protein expression of BZW1 in pancreatic cancer. We then explored the correlation of BZW1 with survival prognosis and immune infiltration in pancreatic cancer patients. Finally, we explored BZW1-related gene enrichment analysis, including protein-protein interaction networks, gene ontology functional enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. The mRNA and protein expression of the BZW1 gene in pancreatic cancer tissues were higher than those in adjacent normal tissues, and pancreatic cancer patients with high BZW1 expression had a poor prognosis. In addition, the expression of BZW1 was positively or negatively correlated with different immune cells of pancreatic cancer, such as CD4 + T lymphocytes, CD8 + T lymphocytes, B cells, macrophages, neutrophils, etc. Correlation enrichment analysis showed that we obtained 50 available experimentally determined BZW1-binding proteins and 100 targeted genes related to BZW1, and the intersection genes were eukaryotic translation termination factor 1 and Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3. Moreover, there was a positive correlation between BZW1 and eukaryotic translation termination factor 1 and Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3 genes in pancreatic cancer. Gene ontology enrichment analysis showed BZW1 was mainly related to biological processes such as “mRNA processing,” “RNA splicing,” “regulation of translational initiation,” and “activation of innate immune response.” The results of Kyoto Encyclopedia of Genes and Genomes pathway analysis further indicated that BZW1 may be involved in pancreatic carcinogenesis through the “spliceosome” and “ribosome.” The BZW1 gene may be a potential immunotherapy target and a promising prognostic marker for pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma

Luo,

Qiao,

et al. 2024

Medicine

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“…BZW1 and BZW2 have been established to promote the malignant progression of several cancers. Shi et al indicated that BZW1 overexpression could promote prostate cancer cell proliferation by regulating TGF-β/Smad pathway ( Shi et al, 2021 ). Jin et al showed that overexpression of BZW2 in hepatocellular carcinoma cells significantly stimulated the activation of PI3K/AKT/mTOR pathway ( Jin et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Expression, oncological and immunological characterizations of BZW1/2 in pancreatic adenocarcinoma

Xiao

et al. 2022

Front. Genet.

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Background: Despite the progress in early diagnosis and treatment, prognosis of pancreatic adenocarcinoma (PAAD) is still poor. Basic leucine zipper and W2 domain-containing protein 1 (BZW1) and protein 2 (BZW2) are attached to the basic leucine zipper (bZIP) superfamily. Recently, BZW1 was identified as an important role in glycolysis of PAAD. However, the comprehensive reports about BZW1/2 in PAAD are not sufficient.Methods: RNA-seq data in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were retrospectively analyzed. We explored the expression of BZW1/2 in PAAD tissues and the associations between BZW1/2 and prognosis. In addition, the potential roles of BZW1/2 in tumor microenvironment (TME) of PAAD were analyzed. Finally, clinicopathological data of 49 patients with PAAD in our institution were collected. Immunohistochemistry was used to determine the expression of BZW1/2 in PAAD samples.Results: BZW1 and BZW2 were upregulated in PAAD tissues compared to normal tissues (p < 0.05). The expression of BZW1/2 were not significantly correlated with gender, grade and stage of PAAD (p > 0.05). High expression of BZW2 was an independent predictor for poor prognosis of PAAD (HR 1.834, 95%CI 1.303–2.581, p = 0.001). And a nomogram to predict overall survival (OS) of PAAD was established with a C-index of 0.685. BZW1 and BZW2 expression were positively associated with T cell mediated immune response to tumor cell and Th2 cells in xCell database. Tumor Immune Single-Cell Hub (TISCH) analyses indicated that BZW1 and BZW2 were mainly expressed in B cells and malignant cells. External cohort furtherly validated that high expression of BZW1 and BZW2 were predictors for poor prognosis of PAAD.Conclusion: We found that BZW1 and BZW2 are highly expressed in malignant cells and B cells in the TME of PAAD. BZW2 is an independent predictor for OS of PAAD. BZW1 and BZW2 expression are positively associated with T cell mediated immune response to tumor cell and Th2 cells in PAAD.

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“…Some studies have reported that BZW1 is highly expressed in cancer tissues and cell lines such as prostate cancer and lung adenocarcinoma 14 , 41 , 42 . BZW1 can promote cell proliferation in prostate cancer by regulating the transforming growth factor-beta1 (TGF-β1)/SMAD pathway 42 . Considering that some of the Bzw1 RNAi embryos were arrested at the cleavage stage (Fig.…”

Section: Discussionmentioning

confidence: 99%

Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation

Zhang

et al. 2022

Nat Commun

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Protein synthesis is an essential step in gene expression during the development of mammalian preimplantation embryos. This is a complex and highly regulated process. The accuracy of the translation initiation codon is important in various gene expression programs. However, the mechanisms that regulate AUG and non-AUG codon initiation in early embryos remain poorly understood. BZW1 is a key factor in determining the mRNA translation start codon. Here, we show that BZW1 is essential for early embryonic development in mice. Bzw1-knockdown embryos fail to undergo compaction, and show decreased blastocyst formation rates. We also observe defects in the differentiation capacity and implantation potential after Bzw1 interference. Further investigation revealed that Bzw1 knockdown causes the levels of translation initiation with CUG as the start codon to increase. The decline in BZW1 levels result in a decrease in protein synthesis in preimplantation embryos, whereas the total mRNA levels are not altered. Therefore, we concluded that BZW1 contributes to protein synthesis during early embryonic development by restricting non-AUG translational initiation.

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BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway

Cited by 13 publications

References 22 publications

BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma

BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma

Expression, oncological and immunological characterizations of BZW1/2 in pancreatic adenocarcinoma

Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation

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