C-12 * Working Memory and fMRI Correlates of Smoking Cessation Treatment Outcome

Hawkshead, Brittany E.; Liebel, Spencer W.; Schwarz, Nicolette F.; Sweet, Lawrence H.

doi:10.1093/arclin/acu038.193

Archives of Clinical Neuropsychology

2014

DOI: 10.1093/arclin/acu038.193

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C-12 * Working Memory and fMRI Correlates of Smoking Cessation Treatment Outcome

Brittany E. Hawkshead¹,

Spencer W. Liebel²,

Nicolette F. Schwarz³

et al.

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2016

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“…Recent findings suggest that suboptimal working memory functioning hinders the ability to successfully quit smoking. Specifically, studies have demonstrated that behavioral and neurobiological markers of deficient performance and/or inadequate effort during tasks thought to require working memory are associated with poor outcomes (e.g., more rapid relapse) in those trying to stop using cigarettes (see also: Day et al, 2014; Hawkshead et al, 2014; Loughhead et al, 2015; Patterson et al, 2010). …”

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confidence: 99%

Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

MacLean

Nichols

LeBreton

et al. 2016

Cogn Affect Behav Neurosci

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Smoking cessation failures are frequently thought to reflect poor top-down regulatory control over behavior. Previous studies suggest that smoking cues occupy limited working memory resources, an effect that may contribute to difficulty achieving abstinence. Few studies have evaluated the effects of cognitive load on the ability to actively maintain information in the face of distracting smoking cues. The current study adapted an fMRI probed recall task under low and high cognitive load with three distractor conditions: control, neutral images, or smoking-related images. Consistent with a limited-resource model of cue reactivity, we predicted that performance of daily smokers (n=17) would be most impaired when high load was paired with smoking distractors. Results demonstrated a main effect of load, with decreased accuracy under high, compared to low, cognitive load. Surprisingly, an interaction revealed the effect of load was weakest in the smoking cue distractor condition. Along with this behavioral effect, we observed significantly greater activation of the right inferior frontal gyrus (rIFG) in the low load condition relative to the high load condition for trials containing smoking cue distractors. Furthermore, load-related changes in rIFG activation partially mediated the effects of load on task accuracy in the smoking cue distractor condition. These findings are discussed in the context of prevailing cognitive and cue reactivity theories. Results suggest that high cognitive load does not necessarily make smokers more susceptible to interference from smoking-related stimuli, and that elevated load may even have a buffering effect in the presence of smoking cues under certain conditions.

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mentioning

confidence: 99%

Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

MacLean

Nichols

LeBreton

et al. 2016

Cogn Affect Behav Neurosci

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C-12 * Working Memory and fMRI Correlates of Smoking Cessation Treatment Outcome

Cited by 1 publication

References 0 publications

Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

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