C’3 Participation in the Rejection of Some Experimental Tumors

Bellelli, L; Sezzi, Maria Luisa

doi:10.1159/000225148

Cited by 7 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some of these cytokines have direct cytotoxic effect on tumor cells while others act on other cells and activate them: natural killer cells and cytotoxic T lymphocytes. In addition, these cytokines might stimulate production of C-reactive protein and complement factor C3 that would act as opsonins on tumor cells (Bellelli and Sezzi, 1976). The combination of these effects might impede tumor growth and lead to elimination of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages

Oršolić

Basić

2005

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages

Oršolić

Basić

2005

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…In addition, these cytokines might stimulate production of C-reactive protein and complement factor C3 that would act as opsonins on tumor cells. 43) The combination of these effects might impede tumour growth and lead to elimination of tumour cells. It is likely that for antitumor effect close contact of test components (especially flavonoids) and tumor cells are more important for cytotoxic effect to tumor cells and induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Synergystic Antitumor Effect of Polyphenolic Components of Water Soluble Derivative of Propolis against Ehrlich Ascites Tumour

Oršolić

Kosalec

Basić

2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Malignant diseases are responsible for the death of about one fifth of the population. The target of much research has been on the discovery of natural and synthetic compounds that can be used in the prevention and/or treatment of cancer. Many plants and animal extracts have shown various biological activities like immunopotentiating and antitumour activities. Honey bee propolis and its components (caffeic acid, caffeic acid phenethyl ester, artepilin C, quercetin, naringenin, resveratrol, galangin, genistein and other) are of the most promising as antitumour agent. [1][2][3][4][5][6][7][8] Propolis (bee glue) is the generic name for the resinous substance collected by honey bees from various plant sources and used by bees to seal holes in their honeycombs, smooth out the internal walls, and protect the entrance against intruders.1) It is rich in biochemical constituents, including mostly a mixture of polyphenols, flavonoid aglycones, phenolic acid and their esters, and phenolic aldehydes and ketones, terpenes, sterols, vitamins, amino acids, etc.2) Healing properties of propolis are known in folk medicine from antiquity. Recently, the interest for propolis as a harmless medicine is increasing. There have been many attempts to validate biological effects of propolis and elucidate its composition. [3][4][5][6][7][8] It was shown that propolis and its constituents have strong antimicrobial effect, acting on viruses, 9-11) bacteria, [12][13][14] and fungi. 15,16) It was also demonstrated that propolis and some of its active substances have a pronounced cytostatic, anticarcinogenic and antitumour effect both in "in vitro" and "in vivo" tumor models. [6][7][8][17][18][19][20][21][22] Immunomodulatory effects of propolis has also been recorded. [23][24][25][26] It has been suggested that the therapeutic activities of propolis depend mainly on the presence of flavonoids.28) Flavonoids have also been reported to induce the immune system, 29,30) and to act as strong oxygen radical scavengers. Dietary intake of antioxidant has been associated with a diminished risk of cancer at various anatomical sites. 31) This led us to compare how the routes (oral and/or systemic) of administration of different polyphenolic compounds deriving from propolis and of propolis itself influence on Ehrlich ascites tumor growth. Thus, we analyzed not only tumor growth but also parameters of immunomodulatory response of animals inoculated with test compounds, determining the effect of them on polymorphonuclear (PMN) and mononuclear (MN) cells, mainly macrophages. MATERIALS AND METHODSWater-Soluble Derivative of Propolis (WSDP) Treatment A water-soluble derivative of propolis (WSDP) was prepared by the method described elsewhere. 32) Briefly, Croatian propolis from beehives kept at the outskirts of Zagreb, Croatia or Brazilian propolis (CONAP, Belo Horizonte, Minas Gerais, Brazil) was extracted with 96% ethanol, which was filtered and evaporated to dryness in vacuum evaporator. The resultant resinous product was added to a stirred solution of 8%...

show abstract

“…Some of these cytokines may express direct cytotoxic effect on tumour cells while others act on NK cells and cytotoxic T lymphocytes. In addition, these cytokines might stimulate production of antibody, C-reactive protein and complement factor C3 that could act as opsonins to tumour cells (Bellelli and Sezzi 1976) and as such activate antibodydependent cellular toxicity. The combination of these effects might impede tumour growth and lead to elimination of tumour cells.…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic compounds from propolis modulate immune responses and increase host resistance to tumour cells

Oršolić

Terzić

Šver

et al. 2005

Food and Agricultural Immunology

View full text Add to dashboard Cite

Propolis contains a variety of polyphenolic compounds. We investigated the effect of a watersoluble derivative of propolis (WSDP) and polyphenolic compounds, components of propolis, on growth of Ehrlich ascites tumour (EAT) in mice. Tumour in peritoneal cavity was produced by 2)/10 6 EAT cells. WSDP and polyphenolic compounds (caffeic acid-CA, caffeic acid phenethyl ester-CAPE and quercetin-QU) were given to mice perorally (po ). It was found that the volume of ascitic fluid induced by EAT cells and total number of cells present in the peritoneal cavity was markedly reduced in EAT-bearing mice treated with test components and the survival time of treated mice was prolonged. Inhibition of EAT growth was due to their effect on the immune system of mice. When innate and acquired immune responses were evaluated, a dose-related increase of cytotoxic T-cell, NK and B cells activity was observed in test components-treated mice. Furthermore, exposure of animals to test components increased functional activity of macrophages to produce factors regulating the function of B-, T-, and NKcells respectively. In conclusion, these findings imply that the antitumour activity of WSDP and polyphenolic compounds of propolis enhanced host resistance in the EAT tumour model, increasing the activities of macrophages, cytotoxic T cells, B cells and NK cells.

show abstract

C’3 Participation in the Rejection of Some Experimental Tumors

Cited by 7 publications

References 8 publications

Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages

Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages

Synergystic Antitumor Effect of Polyphenolic Components of Water Soluble Derivative of Propolis against Ehrlich Ascites Tumour

Polyphenolic compounds from propolis modulate immune responses and increase host resistance to tumour cells

Contact Info

Product

Resources

About