C D 34 and Mast Cell Analysis in Normal Oral Mucosa and Different Grades of Oral Squamous Cell Carcinoma: A Comparative Study

Kathuriya, Pargatsingh; Bartake, Anirudha; Palaskar, Sangeeta; Narang, Bindiya; Patil, Sachin; Pawar, Rasika

doi:10.7860/jcdr/2015/12656.6223

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…MCD was found to be significantly higher in the OSCC group compared with the normal mucosal group. These findings were similar to those reported by many previous studies on various tumors (1,4,5,9,10,(15)(16)(17)(18).…”

Section: Discussionsupporting

confidence: 93%

Mast Cells Density in Hyperkeratosis, Dysplastic Oral Mucosa and Oral Squamous Cell Carcinoma

Torabi

Haghani

Hashemipour

et al. 2018

Avicenna J Dent Res

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Background: Mast cells normally present in small numbers in the connective tissue of all organs and release a variety of potent mediators like histamine, leukotrienes, cytokines, chymase, basic fibroblast growth factor (bFGF), tryptase and heparin through degranulation. Objectives: The aim of the present study was the assessment of mast cell density in hyperkeratosis, dysplastic oral mucosa and oral squamous cell carcinoma (OSCC). Methods: In this retrospective analytical study, paraffinized specimens from 15 cases of normal mucosa and 23 cases of well-differentiated OSCC, cases of hyperkeratosis and dysplasia were selected. Sections were stained with toluidine blue and then were counted at 400× magnification in hotspot areas under a light microscope. The results were analyzed using ANOVA. P values less than 0.05 were considered significant. Results: Mast cells density (MCD) increased in hyperkeratosis, dysplasia, and OSCC. There was not any significant correlation between mast cell density and hyperkeratosis, dysplastic mucosa and normal mucosa. There were significant differences between mast cell counts in SCC and normal mucosa. Conclusions: MCD is higher in hyperkeratosis and dysplastic oral mucosa than in normal mucosa. There were significant differences between mast cell counts in SCC and normal mucosa.

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Section: Discussionsupporting

confidence: 93%

Mast Cells Density in Hyperkeratosis, Dysplastic Oral Mucosa and Oral Squamous Cell Carcinoma

Torabi

Haghani

Hashemipour

et al. 2018

Avicenna J Dent Res

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“…Mast cells influence the primary tumor mainly by the production of many pro-angiogenic factors, such as VEGF, bFGF, TGF, TNF-α, tryptase, heparin and various MMPs, which are associated with ECM degradation, angiogenesis, progression and growth of OSCC [245, 246]. Mast cell and microvessel densities are increased in OSCC compared with normal mucosa, however, no significant correlation has been found [247–251]. Various studies focused on the presence of NK cells in HNSCC patients, in which an increased number of NK cells predicted improved survival [252, 253].…”

Section: Introductionmentioning

confidence: 99%

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

2019

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The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.

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“…In our study, NNM had high MCD (67.85 cells/mm 2 ) and a predominance of granulated MCs was observed in all cases. Kathuriya et al, 29 Zaidi and Mallick, 30 and Pyziak et al 17 found low MCD in NNM samples: 32.85, 22.75, and 27.3 cells/mm 2 , respectively. In addition, Zaidi and Mallick 30 found 61% of granulated MCs in NNM samples.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Dantas¹,

Souza

Valverde

et al. 2017

Applied Immunohistochemistry &Amp; Molecular Morphology

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The objective of this study was to compare mast cell density (MCD) in oral epithelial dysplasias (OED) and oral squamous cell carcinoma (OSCC) and determine its correlation with clinical and histopathologic parameters and the degree of tumor differentiation. Thirty OSCC samples, 14 OED samples, and 4 non-neoplastic oral mucosa samples were analyzed by immunohistochemistry to determine MCD based on the expression of MC tryptase. In addition, MCs were categorized morphologically into degranulated and granulated cells. MCD was significantly higher in OSCC lesions with a greater degree of differentiation (P=0.04). No significant difference in MCD was detected between mild and moderate OED samples (P=0.09). Our findings indicate that MCs are present in the tumor microenvironment and may be associated with a better prognosis.

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C D 34 and Mast Cell Analysis in Normal Oral Mucosa and Different Grades of Oral Squamous Cell Carcinoma: A Comparative Study

Cited by 6 publications

References 24 publications

Mast Cells Density in Hyperkeratosis, Dysplastic Oral Mucosa and Oral Squamous Cell Carcinoma

Mast Cells Density in Hyperkeratosis, Dysplastic Oral Mucosa and Oral Squamous Cell Carcinoma

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

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