C. Difficile Enteritis After Total Proctocolectomy Successfully Treated With Fecal Transplant

Miao, Chuan L.; Mowery, Andrew; Khara, Harshit S.; Shellenberger, Matthew; Komar, Michael

doi:10.14309/00000434-201410002-01500

Cited by 1 publication

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“…At the Centre for Digestive Diseases (CDD), we have had a total of 3 patients with sub-total colectomy for whom FMT failed to cure their CDI, even with combined, repeated nasojejunal and colonic transcolonoscopic infusions; these patients have continued to have CDI for up to 7 years. There has been one publication [ 31 ], however, in which FMT via nasoduodenal administration cured a patient after total proctocolectomy of CDI in the remaining small bowel.…”

Section: Expanding Use Of Fmt For CDI In Specialised Clinical Situmentioning

confidence: 99%

Fecal Microbiota Transplantation: Expanding Horizons for Clostridium difficile Infections and Beyond

Borody

Peattie²,

Mitchell

2015

Antibiotics

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Fecal Microbiota Transplantation (FMT) methodology has been progressively refined over the past several years. The procedure has an extensive track record of success curing Clostridium difficile infection (CDI) with remarkably few adverse effects. It achieves similar levels of success whether the CDI occurs in the young or elderly, previously normal or profoundly ill patients, or those with CDI in Inflammatory Bowel Disease (IBD). While using FMT to treat CDI, however, we learned that using the procedure in other gastrointestinal (GI) diseases, such as IBD without CDI, generally fails to effect cure. To improve results in treating other non-CDI diseases, innovatively designed Randomized Controlled Trials (RCTs) will be required to address questions about mechanisms operating within particular diseases. Availability of orally deliverable FMT products, such as capsules containing lyophilised fecal microbiota, will simplify CDI treatment and open the door to convenient, prolonged FMT delivery to the GI tract and will likely deliver improved results in both CDI and non-CDI diseases.

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Section: Expanding Use Of Fmt For CDI In Specialised Clinical Situmentioning

confidence: 99%

Fecal Microbiota Transplantation: Expanding Horizons for Clostridium difficile Infections and Beyond

Borody

Peattie²,

Mitchell

2015

Antibiotics

View full text Add to dashboard Cite

show abstract

C. Difficile Enteritis After Total Proctocolectomy Successfully Treated With Fecal Transplant

Cited by 1 publication

References 0 publications

Fecal Microbiota Transplantation: Expanding Horizons for Clostridium difficile Infections and Beyond

Fecal Microbiota Transplantation: Expanding Horizons for Clostridium difficile Infections and Beyond

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