C/EBP is an essential component of PDGFRA transcription in MG-63 cells

Afink, Gijs B.; Westermark, Ulrica; Lammerts, Ellen; Nistér, Monica

doi:10.1016/j.bbrc.2004.01.056

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…PDGFR-α and PDGFR-β promoter-luciferase fusion gene constructs were generated as previously described (41)(42)(43). BCE-human telomerase reverse transcriptase-positive (BCE-hTERT + ) cells were maintained in DMEM containing 10% FBS, 100 U/ml penicillin, and 100 μg/ml streptomycin.…”

Section: Methodsmentioning

confidence: 99%

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Nissen¹,

Cao²,

Hedlund³

et al. 2007

J. Clin. Invest.

255

205

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Section: Methodsmentioning

confidence: 99%

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Nissen¹,

Cao²,

Hedlund³

et al. 2007

J. Clin. Invest.

255

205

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“…This finding suggested the presence of multiple binding sites for Phf14 around the transcription start site or that Phf14 is a component of a transcription regulatory complex that recognizes different binding sites. It has been reported that the CCAAT/enhancer-binding protein could bind directly to several conserved binding elements in this ϳ250-bp region, implying that this region may play an important role for transcriptional regulation of PDGFR␣ (33). To clarify whether Phf14 binds to any portion of this ϳ250-bp region directly or not, we examined an in vitro DNA binding assay.…”

Section: Up-regulated Pdgfr␣ Expression Is Associated With Enhanced Pmentioning

confidence: 99%

Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-α

Kitagawa

Takebe

Ono³

et al. 2012

Journal of Biological Chemistry

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Background: Phf14 is identified as a novel gene that regulates proliferation of mesenchymal cells. Results: Phf14-null mice show interstitial pulmonary hyperplasia and mesenchymal fibroblasts exhibit increased proliferation rates accompanied by enhanced expression of PDGFR␣. Conclusion: Phf14 acts as a negative regulator of PDGFR␣ expression in mesenchymal cells. Significance: Phf14 has potential as a target for the treatment of lung fibrosis.

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“…18 19 A number of transcription factors (GATA4, C/EBP, PBX) have been identified which regulate PDGFRA promoter activity in cultured cells in response to extracellular signals. [20][21][22][23] A similar role in vivo for these transcription factors remains to be established.…”

mentioning

confidence: 99%

A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas

Bustos

Smits²,

Strömberg³

et al. 2005

Journal of Medical Genetics

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Background: Platelet derived growth factor receptor a (PDGFRa) expression is typical for a variety of brain tumours, while in normal adult brain PDGFRa expression is limited to a small number of neural progenitor cells. The molecular mechanisms responsible for the PDGFRa expression in tumours are not known, but in the absence of amplification, changes in transcriptional regulation might be an important factor in this process. Methods and results:We have investigated the link between single nucleotide polymorphisms (SNPs) within the PDGFRa gene promoter and the occurrence of brain tumours (medulloblastomas, supratentorial primitive neuroectodermal tumours (PNETs), ependymal tumours, astrocytomas, oligodendrogliomas, and mixed gliomas). These SNPs give rise to five different promoter haplotypes named H1 and H2a-d. It is apparent from the haplotype frequency distribution that both PNET (10-fold) and ependymoma (6.5-fold) patient groups display a significant over-representation of the H2d haplotype. The precise functional role in PDGFRa gene transcription for the H2d haplotype is not known yet, but we can show that the H2d haplotype specifically disrupts binding of the transcription factor ZNF148 as compared to the other promoter haplotypes. Conclusions: The specific over-representation of the H2d haplotype in both patients with PNETs and ependymomas suggests a functional role for the ZNF148/PDGFRa pathway in the pathogenesis of these tumours.

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C/EBP is an essential component of PDGFRA transcription in MG-63 cells

Cited by 10 publications

References 25 publications

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-α

A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas

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