C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Pulido-Salgado, Marta; Vidal-Taboada, José M.; Saura, Josep

doi:10.1016/j.pneurobio.2015.06.003

Cited by 93 publications

(150 citation statements)

References 441 publications

(520 reference statements)

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“…It is involved in memory formation and synaptic plasticity in the central nervous system (14, 15). The promoter region of the Ehmt2 gene contains a consensus binding motif of C/EBPβ and is transactivated by C/EBPβ in human embryonic kidney (HEK) 293T cells (16).…”

Section: Introductionmentioning

confidence: 99%

The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity

Mao

Liang

et al. 2017

Sci. Signal.

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Section: Introductionmentioning

confidence: 99%

The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity

Mao

Liang

et al. 2017

Sci. Signal.

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“…The difference might be attributed to different target gene or different treatment (ox-LDL vs TNF-α). Furthermore, C/EBPβ-upregulated p65 is likely due to mechanisms other than direct transcriptional activation, as no direct C/EBPβ binding site in the p65 gene has been found [22,40]. IκBα may be one of the possible candidates that are upstream of p65 as previous study showed that C/EBPβ enhanced NF-κB-associated signaling by reducing the level of IκBα [42].…”

Section: Discussionmentioning

confidence: 96%

“…In addition, nuclear factor-kappa B (NF-κB), a protein complex composed of IκB bound to two proteins (p50 and p65), is the classical pathway in IL-1β production [21]. C/EBPβ has functional interaction with NF-κB p65 subunit, but the relationship of these two factors is still to be elucidated [22,23].…”

Section: Introductionmentioning

confidence: 99%

C/EBPβ Acts Upstream of NF-κB P65 Subunit in Ox-LDL-Induced IL-1β Production by Macrophages

Liu

Yang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Interleukin-1β (IL-1β) is one of the critical inflammatory factors during atherogenesis. CCAAT/enhancer binding proteins β (C/EBPβ), a regulator of IL-1β production, recently been evidenced as a key player in the development of atherosclerosis. However, the mechanisms of how C/EBPβ regulates the production of IL-1β are unclear. In this study, we aimed to explore the role of C/EBPβ in regulating IL-1β production in macrophages after oxidized low-density lipoprotein (ox-LDL) exposure and the underlying mechanisms. Methods: RAW264.7 macrophages were treated with 0, 25, 50 or 100 μg/ml ox-LDL for 12, 24 or 48 h. Small interfering RNAs were used to silence related proteins. The gene and protein expression levels were determined by quantitative real-time polymerase chain reaction or western blot (WB). IL-1β secretion was assessed by enzyme-linked immunosorbent assay. The cytoplasmic and nuclear proteins were evaluated by nuclear fractionation followed by WB. Localization of p65 was observed by immunofluorescence. The binding activity of p65 to IL-1β was tested by dual-luciferase reporter assay. Results: Ox-LDL increased IL-1β production, accompanied with increasing C/EBPβ and p65 expression in a dose- and time-dependent manner. Moreover, C/EBPβ deficiency in macrophages blocked ox-LDL-induced increases in IL-1β expression, maturation as well as p65 activation. However, p65 deficiency inhibited the increase in IL-1β production, but not C/EBPβ expression. Dual-luciferase reporter results showed that overexpression of C/EBPβ significantly enhanced binding activity of p65 to IL-1β promoter. In addition, C/EBP 1β deficiency in macrophages abolished the ox-LDL-induced gene transcription increases of IL-1β, IL-6, p65 and caspase-1. Conclusions: Our results demonstrate that C/EBPβ acts upstream of NF-κB p65 subunit in ox-LDL-induced IL-1β production in macrophages and may regulate IL-1β maturation by promoting caspase-1. C/EBPβ may be a promising candidate for the prevention and treatment of atherosclerosis.

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“…CEBPD is important for differentiation, survival, and cell death in many cell types including adipocytes and fibroblasts. The most important transcription factors regulating CEBPD transcription are CREB, SP1, and STAT3 [113].…”

Section: Hair and Scalp Disorders 154mentioning

confidence: 99%

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

Nesterova¹,

Yuryev²

2017

Hair and Scalp Disorders

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Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.

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C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Cited by 93 publications

References 441 publications

The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity

The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity

C/EBPβ Acts Upstream of NF-κB P65 Subunit in Ox-LDL-Induced IL-1β Production by Macrophages

Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

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