C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling

Luo, Yalan; Ge, Peng; Wen, Haiyun; Zhang, Hongjie; Liu, Jin; Dong, Xuanchi; Lan, Bowen; Zhang, Guixin; Yang, Qi; Chen, Hailong

doi:10.2147/jir.s377499

Cited by 6 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with our study, another study has also observed HFD-induced neuroinflammation occurred via the C/EBPβ/AEP pathway ( Liu et al, 2022 ). Meanwhile, C/EBPβ also promoted lipopolysaccharide-induced IL-1β transcription and secretion in alveolar macrophages ( Luo et al, 2022 ), indicating a bidirectional relationship between inflammatory cytokines and C/EBPβ. Furthermore, clinical research showed that patients with depression had elevated IL-1β, IL-6, and TNF-α levels ( Connor and Leonard, 1998 ; Maes et al, 1999 ; Mikova et al, 2001 ).…”

Section: Discussionmentioning

confidence: 99%

Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice

Chen

Wang

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Depression, one of the most common causes of disability, has a high prevalence rate in patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for depression. However, the molecular mechanism coupling diabetes to depressive disorder remains largely unknown. Here we found that the neuroinflammation, associated with high-fat diet (HFD)-induced diabetes and obesity, activated the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) in hippocampal neurons. This factor repressed brain-derived neurotrophic factor (BDNF) expression and caused depression-like behaviors in male mice. Besides, the loss of C/EBPβ expression in C/EBPβ heterozygous knockout male mice attenuated HFD-induced depression-like behaviors, whereas Thy1-C/EBPβ transgenic male mice (overexpressing C/EBPβ) showed depressive behaviors after a short-term HFD. Furthermore, HFD impaired synaptic plasticity and decreased surface expression of glutamate receptors in the hippocampus of wild-type (WT) mice, but not in C/EBPβ heterozygous knockout mice. Remarkably, the anti-inflammatory drug aspirin strongly alleviated HFD-elicited depression-like behaviors in neuronal C/EBPβ transgenic mice. Finally, the genetic delivery of BDNF or the pharmacological activation of the BDNF/TrkB signaling pathway by 7,8-dihydroxyflavone reversed anhedonia in a series of behavioral tests on HFD-fed C/EBPβ transgenic mice. Therefore, our findings aim to demonstrate that the inflammation-activated neuronal C/EBPβ promotes HFD-induced depression by diminishing BDNF expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice

Chen

Wang

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension

Wei,

Cheng,

et al. 2024

Immunity

View full text Add to dashboard Cite

Construction of a Novel RNA Prognostic-Predicting Model for Rectum Adenocarcinoma by Bioinformatics Analysis

Zhu

Lü

Jiao

et al. 2023

j biomed nanotechnol

View full text Add to dashboard Cite

We aimed to construct and validate a prognostic-predicting model of rectum adenocarcinoma (READ) based on RNA-binding protein-related genes (RBPGs) by bioinformatics and statistical analysis. We obtained the expression matrix containing 1542 RBPGs from the RBPDB database through the R package. Then, 126 differentially expressed RBPGs (DE-RBPGs) were obtained by differential expression analysis between groups, among which 63 down-regulated genes and 63 up-regulated genes. Next, Ribonucleoprotein complex biosynthesis and assembly were the primary biological processes (BP) identified by the Gene Ontology (GO) enrichment study, cytoplasmic translation, ncRNA processing, ncRNA and rRNA metabolic process. The functions of cellular components (CC) were closely related to organellar and mitochondrial ribosomes and their subunits, spliceosomal complex, mitochondrial matrix and ribonucleoprotein granule. Then, we put 126 DE-RBPGs into the protein–protein interaction (PPI) network, showing the mutual regulation between each DE-RBPGs. In addition, eight prognostics DE-RBPGs (PDE-RBPGs) were identified by Cox regression analysis, among which DIS3L, EFTUD2, FAM98B, IREB2, NOP58, PDCD7 and STRBP were low-risk PDE-RBPGs (HR less than 1), while GTF3A was a high-risk PDE-RBPG (HR greater than 1). A prognosis model consisting of two PDE-RBPGs (EFTUD2 and FAM98B) was finally optimized. The results of the study of the Receiver Operating Characteristics (ROC) curve and the survival analysis revealed that the prognostic-predicting model constructed by us could accurately predict the grouping and prognosis of READ patients. The above results further elucidated the important molecular functions, key biological pathways and gene (protein) interactions of DE-RBPGs. The prognostic-predicting model constructed by us can accurately predict the patients with READ, which is very valuable as a guide for READ early clinical evaluation and therapy.

show abstract

C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling

Cited by 6 publications

References 46 publications

Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice

Inflammation-activated C/EBPβ mediates high-fat diet-induced depression-like behaviors in mice

Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension

Construction of a Novel RNA Prognostic-Predicting Model for Rectum Adenocarcinoma by Bioinformatics Analysis

Contact Info

Product

Resources

About