CH Bond Alkylation (Including Hydroarylation of Alkenes)

Jean‐Gérard, Ludivine; Jazzar, Rodolphe; Baudoin, Olivier

doi:10.1002/9783527655588.ch19

Cited by 5 publications

(2 citation statements)

References 188 publications

(123 reference statements)

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“…This approach has enabled the synthesis of many compounds of interest, such as natural products, materials, and pharmaceuticals. 1 During the last two decades, palladium(II) has unarguably been in the limelight when accomplishing C−H bond-activation reactions, 2 although other transition metals, such as rhodium(III), 3 ruthenium(II), 4 and iridium(III), 5 have also been capable of efficiently carrying out these kinds of transformations. Nonetheless, the use of the aforementioned second-and third-row-transition metals comes with the disadvantage of toxicity and high cost.…”

Section: Introductionmentioning

confidence: 99%

Cp*Co(III)-Catalyzed C–H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool

2020

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The use of earth-abundant first-row transition metals, such as cobalt, in C–H activation reactions for the construction and functionalization of a wide variety of structures has become a central topic in synthetic chemistry over the last few years. In this context, the emergence of cobalt catalysts bearing pentamethylcyclopentadienyl ligands (Cp*) has had a major impact on the development of synthetic methodologies. Cp*Co(III) complexes have been proven to possess unique reactivity compared, for example, to their Rh(III) counterparts, obtaining improved chemo- or regioselectivities, as well as yielding new reactivities. This perspective is focused on recent advances on the alkylation and alkenylation reactions of (hetero)arenes with alkenes and alkynes under Cp*Co(III) catalysis.

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Section: Introductionmentioning

confidence: 99%

Cp*Co(III)-Catalyzed C–H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool

2020

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“…This fact motivated us to extend existing methods [ 14 – 15 ] for the synthesis of substituted thioxanthones. We were intrigued by the fact that carbonyl-substituted arenes can undergo a smooth C–H activation and alkylation in the presence of metal catalysts [ 19 ] (for general reviews see [ 20 – 21 ]). However, there are only few examples [ 14 – 15 ] with sulfur-containing heterocycles as in general sulfur inhibits the catalytic activity of many transition metal catalysts [ 22 ].…”

Section: Introductionmentioning

confidence: 99%