C–H heteroarylation of aromatics via catalyst free S_N2′ coupling cycloaromatization

Abstract

The construction of carbon–carbon bond is the most fundamental aspect of synthetic chemistry. In this study, we developed a catalyst-free SN2' reaction of -OTf-substituted enamides with aromatics to obtain aryl-substituted...

Synthesis of N-vinyl isothiocyanates and carbamates by the cleavage of NH-1,2,3-triazoles with one-carbon electrophiles

“…This difference in configurational stability might be caused by lower double bond isomerization barrier for more electron-rich vinylurea derivative, which makes spontaneous isomerization possible. Since β-enamido triflates are bench stable and synthetically useful building blocks amenable to cross-coupling reactions, 21 the development of new routes for their synthesis is sought after.…”