C–H···O and C–H···N Hydrogen Bond Networks in the Crystal Structures of Some 1,2-Dihydro-N-aryl-4,6-dimethylpyrimidin-2-ones

Conformational tuning of molecular network stabilized via C-H….π & π-π interaction in 2-[2-(3-cyano-4, 6-dimethyl-2-oxo-2H-pyridin-1-yl-methyl)-benzyloxy]-4, 6-dimethyl-nicotinonitrile

“…IR spectra were recorded on Varian 3100 FT-IR spectrometer. 1 H and 13 C -NMR spectra were recorded on a JEOL AL 300 MHz FTNMR instrument. NMR data is represented as follows: chemical shifts δ (in ppm relative to δ TMS = 0), multiplicity, coupling constant J (quoted in hertz, Hz) integration and assignment.…”

Glutaric acid–2-(pyridin-4-yl)-1H-benzimidazole (1/1)

“…For background to hydrogen bonds, see: Moorthy et al (2002); Muthuraman et al (2000); Nangia & Desiraju (1999); Bhattacharjya et al (2004). For related structures, see: Bei et al (2000); Ozbey et al (1998).…”

“…The strong (O-H···O) and weak (C-H···O) hydrogen bonds, the halogen bond (C-X···O) and the weak C-H···π interaction, have been well characterized and exploited in the design of molecular assemblies (Moorthy et al, 2002;Muthuraman et al, 2000;Nangia and Desiraju, 1999;Bhattacharjya et al, 2004). Our interest in benzimidazole stems from their biological activity (Bei et al, 2000;Ozbey et al, 1998).…”

Synthesis of Diphenyl Pyridazinone-based flexible system for conformational studies through weak noncovalent interactions: Application in DNA binding

“…11 [12][13][14][15] The binding affinity of DNA with ligands through noncovalent interaction occurs via several modes, such as, (i) electrostatic attractions with the anionic sugarphosphate backbone of DNA, (ii) interactions with the DNA major groove, (iii) interactions with the DNA minor groove, (iv) intercalation between base pairs via the DNA major groove, (v) intercalation between base * For correspondence pairs via the DNA minor groove, (vi) a threading intercalation mode, etc. [16][17][18] Normally, binding mode of ligands with DNA for most favourable free energy of complex formation depends on structural features of flexible ligands. 17 This work deals with synthesis of symmetrical diphenyl pyridazinone based flexible dimer, namely, 2,2'-(azanediylbis(ethane-2,1-diyl))bis(3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carbonitrile) (3) (scheme 1), linked through diethylamine spacer for conformational studies through crystal structure in solid state.…”