Carissa carandas L. – phyto-pharmacological review

Abstract

Objectives Carissa carandas is an evergreen thorny shrub (Apocynaceae family), commonly, known as karonda. It has small berry-shaped fruits, used as additive in many pickles or as a spice in northern India. Methods The present review covers the literature survey from 1968 to 2020. The data have been collected from various journals, books, thesis and some of the electronic search via Internet-based information such as PubMed, Google Scholar, ScienceDirect, EBSCO, online electronic journals, SpringerLink, Wiley and Ayush. Key findings From literature survey, it has been found that the herbal drug contains wide variety of flavonoids, phenolic acids, steroids, volatile oils, lignans, alkaloids, polysaccharides and so on. These phytochemicals exhibit a range of pharmacological activities including antioxidant, anti-inflammatory, antidiabetic, antimicrobial and antifungal properties. Conclusions This current review offers primary data for further research work. The in-vitro evaluations as well as in-vivo models/experiments have provided a biosynthetic observation for its various ethno-pharmacological uses and even pharmacological properties. This review would provide all valuable information which will be beneficiary to conduct some important pharmacokinetic and toxicological research works on human models with respect to ensure the effects of active ingredients in the body and even to validate its safety issues in clinical aspects.

Bioactivities of Karanda (Carissa carandas Linn.) fruit extracts for novel cosmeceutical applications

“…The findings of the DPPH scavenging assay showed the fresh condition of C. carandas extracts, giving better effect than dried condition by the fresh unripe extract was shown the highest scavenging (IC50 29.11 ± 0.23 μg/mL), while the fresh fully ripe extract was displayed weakly active (IC50 46.49 ± 0.34 μg/mL). Thus, the results expressed that the unripe extract was more efficient in resisting free radicals than ripe and fully ripe fruit extract may be due to unripe extract from C. carandas fruit has a good source of vitamin C.[ 19 ] Vitamin C is a natural phytochemical composite with antioxidant qualities with the ability to provide hydrogen atoms and create reasonably stable ascorbyl free radicals. [ 20 ]…”

Evaluation of Biological Activities From Thai Herbal Lozenges

“…Our result was found antioxidant activity of UM based herbal mixture against DPPH and NO radicals rather than lipid peroxidation. There is implied that antioxidant activity of herbal mixture was possessed from Triphala herbs and may synergist with another herb ingredient, such as liquorice root [6] and karanda fruit [8,9,10]. This herbal extract was contained phenolic compounds, flavonoids and saponins.…”

“…Karanda (Carissa carandas L.) fruits are possessed various health promoting effects i.e., antioxidant, antiinflammatory, antidiabetic and antimicrobial activities. Karanda fruits are containing various phytochemical constituents including flavonoids, phenolic acids, steroids, volatile oils, lignans, alkaloids, polysaccharides [8,9]. Recently, we are developing the new UM formula using karanda fruits replaced to Aristolochia sp.…”

Isolation and structural determination of ursane-type triterpene from <i>Neolamarckia cadamba</i> dried leaves

“…Fruits and leaves of Carissa carandas Linn. (F. Apocynaceae) (Naim et al, 1988), a perennial (Fartyal & Kumar, 2014) Indian shrub (S. Singh et al, 2020), contain this isomer of ursolic acid (Aslam et al, 2011;Siddiqui et al, 2003;A. Singh & Uppal, 2015;Tesfaye & Ravichadran, 2018) and has been recently reported to possess potent in vitro cytotoxic activity against human cancer cell lines (Kour et al, 2020).…”