c-Jun, Fra-2, and ATF-2 Immunoreactivity in the Jejunal Tissues of the Healthy Rat

Abstract

The aim of this study was to compare the localization of some activator protein-1 (AP-1) proteins in healthy rat jejunum. For this purpose, the AP-1 members c-Jun, Fra-2, and ATF-2 immunoreactivity (c-Jun-IR, Fra-2-IR, ATF-2-IR) in villus epithelial cells (ECs), intravillous lamina propria cells (LPCs), crypt cells (CCs), and smooth muscle cells (SMCs) were analyzed by immunohistochemical methods. Among all the cell groups, the lowest positivity ratio was found in c-Jun-IR and the highest positivity ratio was found in ATF-2-IR. For each group of ECs, LPCs, CCs, and SMCs, c-Jun-IR, Fra-2-IR, and ATF-2-IR were compared and statistically significant differences found. There were no significant differences among the cell groups with respect to c-Jun-IR and Fra-2-IR, but there was a statistically significant difference in ATF-2-IR. These findings suggest that each member of AP-1 is expressed differently and that ATF-2 is more active than c-Jun and Fra-2 in physiological conditions in healthy rat jejunum.

Immunoreactivity of ATF-2 and Fra-2 in human dental follicle.

“…ATF-2 and Fra-2 which are the members of AP-1 transcription factors play important roles in growth, differentiation, apoptosis and cancer processes in cell [26][27][28][29]. In view of their cellular functions, it can be predicted that these proteins may be effective in cyst formation originating from epithelial cells of DF.…”