c-Jun N-terminal kinase-mediated anti-inflammatory effects of Garcinia subelliptica in macrophages

Cho, Young‐Chang; Cho, Sayeon

doi:10.3892/mmr.2016.4791

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…The ethanol leaf extract of G. subelliptiac reduced nitric oxide production in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. Expression of cyclooxygenase-2 was notably reduced and production of proinflammatory cytokines was inhibited [ 56 ]. From the seed of G. subelliptiac , garcinielliptones (garsubellin A, garcinielliptin oxide, and garcinielliptone F) had potent inhibitory effects on the release of β-glucuronidase and lysozyme, and on superoxide formation from neutrophils stimulated with fMLP/CB [ 28 , 29 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Garcinia subelliptica (Fukugi): A Multi-purpose Coastal Tree with Promising Medicinal Properties

Inoue

Kainuma²,

Baba³

et al. 2017

J Intercult Ethnopharmacol

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In this short review, the current knowledge on the botany, ecology, uses, and medicinal properties of the multipurpose Garcinia subelliptica (Fukugi) is updated. As yet, there are no reviews on this indigenous and heritage coastal tree species of the Ryukyu Islands in Japan, which has ethnocultural, ecological, and pharmacological significance. Planted by the Okinawan people some 300 years ago, Fukugi trees serve as windbreaks and accord protection against the destructive typhoons. The species has become a popular ornamental tree, and its bark has been used for dyeing fabrics. It forms part of the food chain for mammals and insects and serves as nesting sites for birds. Endowed with bioactive compounds of benzophenones, xanthones, biflavonoids, and triterpenoids, G. subelliptica possesses anticancer, anti-inflammatory, anti-tyrosinase, trypanocidal, antibacterial, DNA topoisomerase inhibitory, DNA strand scission, choline acetyltransferase enhancing, hypoxia-inducible factor-1 inhibitory, and antiandrogenic activities. Fukugetin and fukugiside are two novel biflavonoids named after the species. The chemical constituents of Fukugi fruits when compared with those of mangosteen yielded interesting contrasts.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Garcinia subelliptica (Fukugi): A Multi-purpose Coastal Tree with Promising Medicinal Properties

Inoue

Kainuma²,

Baba³

et al. 2017

J Intercult Ethnopharmacol

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“…Of note, the inhibition of TNF-α production was only detected when the extract inhibited NF-κB and all MAPKs, including JNK, ERK and p38 (42). In one instance, TNF-α production was not attenuated when the extract only inhibited one MAPK in addition to NF-κB (43). Therefore, it may be speculated that the MGS-mediated selective inhibition of cytokine production is a consequence of the selective regulation of inflammatory signal transduction, but further studies are needed to confirm the above.…”

Section: Discussionmentioning

confidence: 93%

Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages

Cho

2018

Int J Mol Med

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Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained elusive. In the present study, the anti‑inflammatory effects of the methanol extract of G. speciosa (MGS) were investigated in murine macrophages by measuring the production of inflammatory mediators and the underlying mechanisms of action by performing immunoblotting analysis of proteins that are potentially involved. MGS reduced nitric oxide (NO) production through regulation of the expression of inducible NO synthase (iNOS) in lipopolysaccharide‑activated RAW 264.7 cells; however, cyclooxygenase‑2, the enzyme responsible for prostaglandin E2 production, was not affected at the mRNA or protein level. MGS reduced interleukin‑6 (IL‑6) production, but had no effect on tumor necrosis factor (TNF)‑α production. In addition, MGS suppressed the transcription of IL‑6, but not that of IL‑1β and TNF‑α. The effect of MGS on proinflammatory mediators resulted from the inhibition of the activation of spleen tyrosine kinase and c‑Jun N‑terminal kinase. In conclusion, the present study suggested that MGS may be a potential candidate for development as a therapeutic for alleviating inflammation.

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“…This observation is in line with our study. Further, they established that the decreased secretion of in ammatory mediators by Garcinia subelliptica was associated with a decrease in the activation of cJun Nterminal kinase (JNK) [47]. Evidence suggests that LPS signi cantly induces the secretion of proin ammatory mediators in macrophages by triggering the Mitogen Activated Protein Kinase (MAPK) signaling.…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking Prediction and in Vitro Studies Elucidate Anti-inflammatory Effect of Garcinia Extract Against Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Targets

Kalita

Das

et al. 2021

Preprint

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Garcinia is a tropical plant that has been traditionally used in medicinal folklore for its potential antioxidant, antibacterial, anti-hyperlipidemic, anti-diabetic, hepatoprotective, etc. In this study, Garcinia herbal extract (GHE) and one of its important phytocompound (garcinol) were evaluated for their inhibitory action against important inflammatory markers inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. iNOS and COX-2 plays an major role in the process of inflammation and inhibition of these molecules will help to alleviate the inflammatory process. The cells were pre-treated with two doses of Garcinia (230µg/ml and 115µg/ml); garcinol (12µM and 6µM) followed by stimulation with 1µg/ml of LPS for 24h. The results of the study demonstrated that GHE and garcinol plays an important role in suppressing LPS- induced relative mRNA expression of iNOS, COX-2 and subsequent reduction in the levels of nitric oxide and prostaglandin E 2 . Molecular docking analysis of garcinol and hydroxycitric acid, the major active components of GHE with iNOS and COX-2 proteins showed potent interaction with low binding energies. This study suggests that GHE (containing high percentage of HCA) and garcinol may possess anti-inflammatory activity thus providing a possibility for drug designing as iNOS and COX-2 inhibitors.

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c-Jun N-terminal kinase-mediated anti-inflammatory effects of Garcinia subelliptica in macrophages

Cited by 9 publications

References 42 publications

Garcinia subelliptica (Fukugi): A Multi-purpose Coastal Tree with Promising Medicinal Properties

Garcinia subelliptica (Fukugi): A Multi-purpose Coastal Tree with Promising Medicinal Properties

Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages

Molecular Docking Prediction and in Vitro Studies Elucidate Anti-inflammatory Effect of Garcinia Extract Against Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Targets

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