2013
DOI: 10.1074/jbc.m113.464453
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c-Jun NH2-terminal Kinase (JNK)-interacting Protein-3 (JIP3) Regulates Neuronal Axon Elongation in a Kinesin- and JNK-dependent Manner

Abstract: Background:The role of JIP3 in axon specification and elongation in addition to axon branching remains unknown. Results: JIP3 locally activates the JNK-cofilin pathway at axon tips and thus enhances axon elongation. Conclusion: JIP3 is essential for axon elongation. Significance: These results advance our understanding of the role of JIP3 in axon development.

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Cited by 58 publications
(68 citation statements)
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References 60 publications
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“…In ULK4 knockdown cells, we observed a significant reduction in the phosphorylation of ERK1/2 (P50.001, n53) and p38 MAPKs (P50.003, n53). Upregulated activity of the stress-activated c-Jun N-terminal kinases (JNKs) is highly involved in neuritogenesis, including axon formation, polarization, extension, synaptic plasticity, and dendrite development during brain development or under a stress challenge (Coffey et al, 2000;Rosso et al, 2005;Oliva et al, 2006;Barnat et al, 2010;Qu, et al, 2013;Sun et al, 2013). In line with these reports, we observed consistently decreased expression of phosphorylated JNK in ULK4 knockdown cells (P50.008, n53; Fig.…”
Section: Ulk4 Modulates Erk P38 Mapk Pkc and Jnk Pathwayssupporting
confidence: 79%
See 1 more Smart Citation
“…In ULK4 knockdown cells, we observed a significant reduction in the phosphorylation of ERK1/2 (P50.001, n53) and p38 MAPKs (P50.003, n53). Upregulated activity of the stress-activated c-Jun N-terminal kinases (JNKs) is highly involved in neuritogenesis, including axon formation, polarization, extension, synaptic plasticity, and dendrite development during brain development or under a stress challenge (Coffey et al, 2000;Rosso et al, 2005;Oliva et al, 2006;Barnat et al, 2010;Qu, et al, 2013;Sun et al, 2013). In line with these reports, we observed consistently decreased expression of phosphorylated JNK in ULK4 knockdown cells (P50.008, n53; Fig.…”
Section: Ulk4 Modulates Erk P38 Mapk Pkc and Jnk Pathwayssupporting
confidence: 79%
“…Jnk1 2/2 mice exhibit disrupted anterior commissure tract formation and abnormal axonal microtubule integrity (Chang et al, 2003), as well as altered dendritic architecture (Björkblom et al, 2005). In addition, JNKinteracting protein 3 also promotes axon elongation in a JNKdependent manner through facilitating actin polymerization (Sun et al, 2013). In the present study, the CNV frequency of MAPK8-10 was comparable in the ISC cases and controls, with one MAPK8 duplication plus one MAPK9 partial duplication in the ISC cases, and one MAPK9 plus one MAPK10 partial duplication in the controls.…”
Section: Discussionsupporting
confidence: 51%
“…UNC-16 (JIP3) is also known to regulate axon elongation and branching as well as axonal transport and regeneration after injury (Cavalli et al 2005;Bilimoria et al 2010;Suzuki et al 2010;Sun et al 2013;Nix et al 2014;Watt et al 2015). However, it is unknown whether these axon growth functions of SAD-1 and UNC-16 are related and whether other CSS system proteins also participate.…”
Section: )mentioning
confidence: 99%
“…Indeed, there is genetic evidence in mice that JIP3 can function as an adaptor that promotes the Kinesin-1-mediated transport of TrkB receptors as well as one or more unidentified cargos relevant to axon elongation and neuronal degeneration (Huang et al 2011;Sun et al 2013;Sato et al 2015;Watt et al 2015).…”
mentioning
confidence: 99%
“…Сүн нар [17] болон Ватт нар [18] JSAP нь мотор уургийн идэвх ба хөдөлгөөнийг зохицуулдаг болохыг харуулсан [13][14][15][16][17][18]. Мэдрэлийн эсийн аксоны уртсах, салаалах, мэдрэлийн ширхэг үүсэхэд ч JSAP уургууд чухал үүрэгтэй ажээ [19][20][21][22]. Түүнчлэн эсийн митоз хуваагдлын прометафаз үе болон цитокинезийн үед JSAP уургууд чухал үүрэгтэй болох нь тогтоогдоод байна [23,24].…”
Section: оршилunclassified