c-kit expression identifies cardiovascular precursors in the neonatal heart

Tallini, Yvonne N.; Greene, Kai Su; Craven, Michael; Spealman, Alyson Korry; Breitbach, Martin; Smith, James P.; Fisher, Patti J.; Steffey, Michele A.; Hesse, Michael; Doran, Robert; Woods, Ashley K.; Singh, Babu; Yen, Andrew; Fleischmann, Bernd K.; Kotlikoff, Michael I.

doi:10.1073/pnas.0808920106

Cited by 198 publications

(214 citation statements)

References 24 publications

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“…These data were later supported by other research groups (14,67,73,86,88,113). Several studies have independently described cardiac stem=progenitor cell isolation from various species, including murine, rat, feline, pig, dog, and human, that display stem= progenitor cell characteristics (5,18,60,73,88,117).…”

Section: Cardiac Stem=progenitor Cellssupporting

confidence: 48%

De NovoMyocardial Regeneration: Advances and Pitfalls

Haider

Buccini

Ahmed

et al. 2010

Antioxidants & Redox Signaling

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The capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in most clinical studies with skeletal myoblasts and bone marrow cells has warranted a search for alternative sources of stem cells. Despite their multilineage differentiation potential, ethical issues, teratogenicity, and tissue rejection are main obstacles in developing clinically feasible methods for embryonic stem cell transplantation into patients. A decade-long research on embryonic stem cells has paved the way for discovery of alternative approaches for generating pluripotent stem cells. Genetic manipulation of somatic cells for pluripotency genes reprograms the cells to pluripotent status. Efforts are currently focused to make reprogramming protocols safer for clinical applications of the reprogrammed cells. We summarize the advancements and complicating features of stem cell therapy and discuss the decade-and-a-half-long efforts made by stem cell researchers for moving the field from bench to the bedside as an adjunct therapy or as an alternative to the contemporary therapeutic modalities for routine clinical application. The review also provides a special focus on the advancements made in the field of somatic cell reprogramming.

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Section: Cardiac Stem=progenitor Cellssupporting

confidence: 48%

De NovoMyocardial Regeneration: Advances and Pitfalls

Haider

Buccini

Ahmed

et al. 2010

Antioxidants & Redox Signaling

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“…However, transdifferentiation of these cells into cardiomyocytes is controversial (Orlic et al, 2001;Murry et al, 2004;Bearzi et al, 2007). On the other hand, Tallini (Tallini et al, 2009) reported that c-Kit is expressed by immature cardiomyocytes as well as endothelial cells during development of mouse heart and that the populations rapidly expanded during the first 2 days of postnatal life. Their study compared the difference between the multipotency potential of CPC derived from the neonatal heart and the adult injured heart.…”

Section: Markers Of Cpc In the Postnatal Heartmentioning

confidence: 99%

“…In contrast, they found that cKit + cells in the adult injured mouse heart had no myogenic capacity. The co-expression of cKit and neuronal marker Nestin in neonatal CPC (Tallini et al, 2009) suggests a transitional status of NCC in postnatal life and the potential for NCC contributing to cardiac repair and remodeling (Drapeau et al, 2005).…”

Section: Markers Of Cpc In the Postnatal Heartmentioning

confidence: 99%

Myocardial Self-Repair and Congenital Heart Disease

Chalajour¹,

Ma²,

Riemer³

2012

Congenital Heart Disease - Selected Aspects

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“…GFP) into a gene of interest to visualize the current activity of a specific gene. This has been successfully applied to observe the contributions of c-kit+ cells to the revascularizing infarct regions of the myocardial infarcted heart by utilizing c-kit(BAC)-EGFP mice (Tallini et al, 2009). Labelled cells in the infarct regions were not cardiomyocytes but endothelial and smooth muscle cells.…”

Section: Lineage Tracingmentioning

confidence: 99%