c-kit positive cardiac stem cells as a potential candidate for heart repair, developments, challenges and future implications

Abstract

IntroductionThe c-kit + cardiac stem cells represent the most extensively characterised subset of cardiac stem cell pool. Studies in recent past document these cells to possess substantial cardiac regenerative potential in diverse disease models. The present study aimed to critically review such developments and suggest areas of improvements imperative for effective cell-based therapy. This article is a critical review of studies documenting c-kit + cardiac stem cells as a potential candidate for the repair of damaged heart. Discussion This critical review revealed that c-kit