c-myc oncogene copy number in squamous carcinoma of the head and neck

Haughey, Bruce H.; Hoff, Daniel D. Von; Windle, Braddford E.; Wahl, Geoffrey M.; Mock, Presley M.

doi:10.1016/0196-0709(92)90117-c

Cited by 22 publications

(18 citation statements)

References 13 publications

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“…We assessed, in parallel, c-MYC gene amplification, which has been previ- ously shown to be amplified in various tumor types including HNSCC. [14][15][16][17][18] In this report we provide the first evidence that CENP-F is amplified and overexpressed in a group of HNSCCs.…”

Section: Discussionmentioning

confidence: 89%

“…[27][28][29] The frequency of c-MYC amplification in our series (17%) is on the upper range relative to previous studies that reported frequencies from 7% to 25%. [14][15][16][17][18] Half the tumors had c-MYC amplified at a low-level range from 1.6 to 3-fold. This low-level c-MYC amplification is consistent with previous reports in various tumor types.…”

Section: Discussionmentioning

confidence: 99%

“…Amplification of c-MYC has been reported in 7% to 25% of the HNSCCs. [14][15][16][17][18] The autoantibody response to CENP-F in some patients with cancer, including head and neck cancer, suggests the possibility of CENP-F gene amplification and overexpression.…”

mentioning

confidence: 99%

“…MYC family oncogenes have been observed to be amplified late in the progression of many human tumors and generally associated with an aggressively malignant phenotype. 14,[33][34][35] In this study, we examined samples of tumors and the paired macroscopically normal mucosa from 72 patients, diagnosed with primary HNSCC, for CENP-F and c-MYC gene amplification and CENP-F overexpression. The study was focused at assessing the amplification of CENP-F in HNSCCs using c-MYC as comparison.…”

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confidence: 99%

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Cenp-F gene amplification and overexpression in head and neck squamous cell carcinomas

et al. 2001

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Cenp-F gene amplification and overexpression in head and neck squamous cell carcinomas

et al. 2001

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“…3q amplification has been identified in early tumor development. Although there are some reports of overexpression and/or amplification of several proto-oncogenes, such as bcl-2, ras and c-myc (Haughey et al, 1992;Kiaris et al, 1995;Teni et al, 2002), little is known about the molecular changes associated with tumorigenic transformation.…”

Section: Introductionmentioning

confidence: 99%

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array

Nakaya

Arita

et al. 2007

Oncogene

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Homozygous deletions (HD) provide an important resource for identifying the location of candidate tumor suppressor genes. To identify the tumor suppressor gene in oral cancer, we employed high-resolution comparative genomic hybridization (CGH)-array analysis. We identified a homozygous loss of FAT (4q35), a new member of the human cadherin superfamily, from genome-wide screening of copy number alterations in one primary oral cancer. This result was evaluated by genomic polymerase chain reaction in 13 oral cancer cell lines and 20 primary oral cancers and Southern blot in the cell lines. We found frequent exonic HD of FAT in the cell lines (3/13, 23%) and in primary oral cancers (16/20, 80%). FAT expression was absent in these cell lines. Homozygous deletion hot spots were observed in exon 1 (9/20, 45%) and exon 4 (7/20, 35%). Moreover, loss of gene expression was identified in other types of squamous cell carcinoma. The methylation status of the FAT CpG island in squamous cell carcinomas correlated negatively with its expression. Our results identify mutations in FAT as an important factor in the development of oral cancer and indicate the importance of FATs function in some squamous cell carcinomas.

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