Almost since the time of the discovery of the neutron more than 70 years ago, efforts have been made to understand the effects of neutron radiation on tissue and, eventually, to use neutrons for cancer treatment. In contrast to charged particle or photon radiations which directly lead to release of electrons, neutrons interact with the nucleus and induce emission of several different types of charged particles such as protons, alpha particles or heavier ions. Therefore, a fundamental understanding of the neutron-nucleus interaction is necessary for dose calculations and treatment planning with the needed accuracy. We will discuss the concepts of dose and kerma, neutron-nucleus interactions and have a brief look at nuclear data needs and experimental facilities and set-ups where such data are measured. Figure 1: Cross section for the 16 O(n,γ) reaction (top) and 235U(n,fission) reaction (bottom) plotted as function of the incident neutron energy. The data are from the ENDF/B-VII evaluation and have been retrieved using Janis 3.0 (Soppera et al., 2008).