C-peptide and the classification of diabetes mellitus patients in the Early treatment diabetic retinopathy study report number 6

Prior, Mary Jane; Prout, Thaddeus E.; Miller, Dayton T.; Ewart, Robin; Kumar, Dinesh

doi:10.1016/1047-2797(93)90004-n

Cited by 28 publications

(21 citation statements)

References 31 publications

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“…Although we cannot clearly distinguish between type 1 and type 2 diabetes based on duration of diabetes, BMI, and insulin use, our C-peptide analyses suggest that errors in classification are low [33]. Our ability to determine the exact duration of type 2 diabetes is not possible and is comparable to all other studies of this type.…”

Section: Discussionmentioning

confidence: 61%

Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26

Cusick¹,

Chew²,

Hoogwerf³

et al. 2004

Kidney International

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In this study, major modifiable risk factors such as hypertension, dyslipidemia, and hyperglycemia were found to be predictive of RRT. Other predictors were markers of vascular pathology and inflammation, proteinuria, hypoalbuminemia, and increased serum creatinine. Controlled clinical trials with treatment strategies that improve serum lipid levels, systemic blood pressure, glycemic control, and markers of inflammation may be important in furthering our knowledge on the pathogenesis of diabetic complications such as nephropathy and ESRD.

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Section: Discussionmentioning

confidence: 61%

Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26

Cusick¹,

Chew²,

Hoogwerf³

et al. 2004

Kidney International

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“…The predictive value of the broad classification system developed from these data for use in the ETDRS was 93.4% for type I (IDDM) and 82.8% for type II (NIDDM). 70 Overall, there was a 93.6% agreement between the broad classification system and the classification of diabetes by discriminant analysis (using post-Sustacal C-peptide levels and data available from the ETDRS medical form). On the basis of this information, type of diabetes is likely to be classified correctly for most ETDRS patients.…”

Section: Methods For Assessing Type Of Diabetesmentioning

confidence: 99%

Early photocoagulation in patients with either type I or type II diabetes

Ferris¹

1997

American Journal of Ophthalmology

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“…We chose to classify diabetes type based on duration of diabetes, age at diagnosis, BMI, and insulin use. A previous report (64) in a sample of ETDRS subjects revealed that our clinically derived definitions provide good discrimination between the two types of diabetes.…”

Section: Associations Of Mortality With Diabetes Complicationsmentioning

confidence: 99%

Associations of Mortality and Diabetes Complications in Patients With Type 1 and Type 2 Diabetes

et al. 2005

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OBJECTIVE—Diabetes is a leading cause of morbidity and mortality. The purpose of this study is to assess the associations between diabetes complications and mortality in the Early Treatment Diabetic Retinopathy Study (ETDRS). RESEARCH DESIGN AND METHODS—We examined demographic, clinical, and laboratory characteristics of the 3,711 subjects enrolled in the ETDRS, a randomized controlled clinical trial designed to evaluate the role of laser photocoagulation and aspirin therapy for diabetic retinopathy. The outcome assessed was all-cause mortality. Multivariable Cox proportional hazards regression was used to assess associations between diabetes complications and mortality for type 1 and type 2 diabetes separately. RESULTS—The 5-year estimates of all-cause mortality were 5.5 and 18.9% for patients with type 1 and type 2 diabetes, respectively. In patients with type 1 diabetes, amputation (hazard ratio [HR] 5.08 [95% CI 2.06–12.54]) and poor visual acuity (1.74 [1.10–2.75]) remained significantly associated with mortality, after adjusting for other diabetes complications and baseline characteristics. In patients with type 2 diabetes, macrovascular disease and worsening levels of nephropathy, neuropathy, retinopathy, and visual acuity are associated with progressively increasing risks of mortality, after controlling for other baseline risk factors. CONCLUSIONS—Amputation is the strongest predictor for mortality in patients with type 1 diabetes. All complications independently predict mortality in patients with type 2 diabetes. There is an increased risk for mortality as the degree of each complication worsens. Additional studies are needed to investigate the effectiveness of tertiary prevention to decrease mortality in these patients.

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C-peptide and the classification of diabetes mellitus patients in the Early treatment diabetic retinopathy study report number 6

Cited by 28 publications

References 31 publications

Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26

Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26

Early photocoagulation in patients with either type I or type II diabetes

Associations of Mortality and Diabetes Complications in Patients With Type 1 and Type 2 Diabetes

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