C-Peptide Is a Sensitive Indicator for the Diagnosis of Metabolic Syndrome in Subjects from Central Mexico

González-Mejia, M. Elba; Porchia, Leonardo M.; Torres‐Rasgado, Enrique; Ruiz-Vivanco, Guadalupe; Pulido‐Perez, Patricia; Baez-Duarte, Blanca G.; Pérez-Fuentes, Ricardo

doi:10.1089/met.2015.0067

Cited by 24 publications

(22 citation statements)

References 28 publications

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“…It could be used to represent endogenous insulin secretion by islet β cells and insulin resistance . Studies have found that C‐peptide is significantly associated with NAFLD, being one of the three most important predictors in the general US population, as well as potential risk factors and outcomes of NAFLD, such as cardiovascular diseases and MetS . However, rather limited studies have measured the association between C‐peptide and advanced NAFLD stages.…”

Section: Introductionmentioning

confidence: 99%

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

Wang

Zhang

et al. 2019

Diabetes Metabolism Res

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Background: A higher prevalence of nonalcoholic steatohepatitis (NASH) and advanced stages of fibrosis was observed in type 2 diabetes. We aim to investigate whether C-peptide is associated with nonalcoholic fatty liver disease (NAFLD) progression in type 2 diabetic adults. Methods:A total of 4937 diabetic participants were enrolled from China in 2018.Liver steatosis was detected by ultrasound. Subjects with NAFLD were categorized into simple NAFLD and probable NASH by the concurrent presence of metabolic syndrome. NAFLD fibrosis score was used to identify patients with probable advanced fibrosis.Results: Individuals with a longer history of type 2 diabetes had a lower C-peptide level and a lower prevalence of probable NASH but a higher prevalence of advanced fibrosis. C-peptide was positively associated with simple NAFLD and probable NASH, with odds ratios (ORs) of 4.55 [95% confidence interval (CI) 3.16, 6.55] and 5.28 (95% CI 3.94, 7.09), respectively, comparing quartile 4 with quartile 1 (both p for trend <0.001). However, C-peptide quartiles were negatively associated with the probable presence of advanced fibrosis (Q4 vs. Q1, OR 0.59, 95% CI 0.36, 0.97, p for trend <0.05). A 1-SD increment of ln(C-peptide) was also significantly associated with inflammatory and fibrotic progression (OR 1.34, 95% CI 1.27, 1.41; OR 0.88, 95% CI 0.79, 0.98, respectively).Conclusions: Significant but opposite associations between C-peptide and inflammatory and fibrotic progression of NAFLD were observed. Understanding islet hormone changes during type 2 diabetes and differentiating the stage of NAFLD may help to personalize treatment strategies for NAFLD patients with type 2 diabetes. KEYWORDS

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Section: Introductionmentioning

confidence: 99%

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

Wang

Zhang

et al. 2019

Diabetes Metabolism Res

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“…Encontramos también un aumento significativo de la insulina, con lo que confirmamos el estado hiperinsulinémico de los pacientes con SM+, los mismos hallazgos que fueron descritos por otros autores que obtuvieron resultados similares 32,33 . Además del estado hiperfuncionante secundario al estado de insulinorresistencia, debemos mencionar que el aumento de los niveles de insulina en nuestra población podría ser a su vez potenciado por el uso de medicamentos secretagogos de insulina en la población SM+, efecto que ya se ha corroborado principalmente en los pacientes bajo tratamiento con sulfonilureas.…”

Section: Discussionunclassified

“…Según artículos, en pacientes con SM y en individuos obesos las concentraciones plasmáticas de amilina suelen estar incrementadas; misma situación se encuentra en nuestro estudio donde se aprecian niveles de amilina mayores en pacientes con SM+ en contraste con los SM-(9.9 ± 0.6 vs. 7.8 ± 0.5, pmol/l; p < 0.05) 32,[37][38][39] .…”

Section: Discussionunclassified

El papel de la amilina en la función de la célula B pancreática en pacientes con síndrome metabólico

Plata-Corona¹,

Lara-Solis²,

Pérez-Fuentes³

et al. 2020

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“…In a large community-based survey of adults in china, was conducted by the Yang-Ming Crusade in 1992 and 1994 among a total of 1,447 men and 1,800 women (mean age 46.7 years), found that fasting C-peptide was significantly higher among hypertensive subjects in comparison to normotensives (p= 0.00) 22 .…”

Section: Discussionmentioning

confidence: 99%

Relation between Blood Pressure Control and Insulin Secretion Markers among Elderly Diabetic Females

et al. 2017

The Egyptian Journal of Geriatrics and Gerontology

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Background Ageing is a universal phenomenon; almost 5.3% of the entire population is a major concern to health economists 1. By 2020 it will be 177 million elderly people, aged above 60 years. Ageing process is as such complex and multi-factorial. Chronic morbidities like diabetes and hypertension are becoming common health problems among the geriatric population 2. High geriatric population means a higher number of patients with various chronic diseases and increasing percentage of lifetime health care costs are accounted for this population. Longevity will have a greater chance of developing diseases that occur more commonly during later life; many individuals will also live with chronic illnesses 3. Of all the diseases, diabetes mellitus is one of the most common diseases affecting a large number of elderly populations along with hypertension which play a major role on the quality of life of the elderly and the healthcare costs. Centers for Disease Control and Prevention (CDC) suggest that the prevalence of diabetes will double in the next 20 years, in part due to the aging of the population 4. Several studies showed a significant association between residual beta-cell function and various vascular complications of diabetes including hypertension that is confirmed in a large clinical cohort study of patients with type 1 diabetes, 10. In contrast to these studies in type 1 diabetes, several studies 11-13 have reported conflicting results on the association between serum C-peptide levels and vascular complications in type 2 diabetes.

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C-Peptide Is a Sensitive Indicator for the Diagnosis of Metabolic Syndrome in Subjects from Central Mexico

Abstract: C-peptide is a strong indicator of MetS. Since C-peptide has recently emerged as a biomolecule with significant importance for inflammatory diseases, monitoring C-peptide levels will aid clinicians in preventing MetS.

Cited by 24 publications

References 28 publications

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

El papel de la amilina en la función de la célula B pancreática en pacientes con síndrome metabólico

Relation between Blood Pressure Control and Insulin Secretion Markers among Elderly Diabetic Females

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