C‐Phycocyanin ameliorates 2‐acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice

Roy, Kunal; Nishanth, Reddy P.; Sreekanth, Devalraju; Reddy, Gorla V.; Reddanna, Pallu

doi:10.1111/j.1872-034x.2007.00290.x

Cited by 10 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phycocyanin inhibited the expression of the acetylaminofluorene-induced multidrug resistance protein (MDR1) in the mouse macrophage cell line RAW 264.7 in vitro by scavenging ROS [232] and in the liver of albino mice in vivo by interfering at the level of ROS generation, Akt (protein kinase B) phosphorylation and NF-κB translocation [233]. The same mechanisms (downregulation of ROS and COX-2 pathways via the involvement of NF-κB and activator protein 1 -AP-1, inhibition of MDR1) were confirmed in HepG2 human hepatocarcinoma cell line in relation to prevention of doxorubicin resistance by phycocyanin [126].…”

Section: Other Miscellaneous Medicinal Effectsmentioning

confidence: 99%

Phycobilins and Phycobiliproteins Used in Food Industry and Medicine

Myśliwa-Kurdziel

Solymosi

2017

MRMC

View full text Add to dashboard Cite

show abstract

Section: Other Miscellaneous Medicinal Effectsmentioning

confidence: 99%

Phycobilins and Phycobiliproteins Used in Food Industry and Medicine

Myśliwa-Kurdziel

Solymosi

2017

MRMC

View full text Add to dashboard Cite

show abstract

“…22 However, regarding purified phycocyanin, it was shown an MDR1 gene down-regulation in 2-AAF-causes liver tumors in the first day's treatment. 23 Also, phycocyanin inhibits tumor cell proliferation, and it arrests the tumor cell cycle into G 0 /G 1 through the mitogen-activated protein kinase (MAPK) pathway in vitro models. 24 Despite all findings about spirulina and phycocyanin antitumorigenic action, it is necessary to carry on studies in vivo without tumorigenic drugs, to define the effect of phycocyanin on an experimental model of liver cancer.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect Assessment of C-Phycocyanin on Hepatocellular Carcinoma Rat Model by Using Photoacoustic Spectroscopy

Lizeth,

Vanessa,

María del Rocio

et al. 2024

Appl Spectrosc

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common primary neoplasia of the liver with elevated mortality. Experimental treatment with antioxidants has a beneficial effect on the experimental models of HCC. Arthrospira maxima (spirulina) and its phycocyanin have antitumoral action on different tumoral cells. However, it is unknown whether phycocyanin is the responsible molecule for the antitumoral effect on HCC. Photoacoustic spectroscopy (PAS) stands out among other spectroscopy techniques for its versatility of samples analyzed. This technique makes it possible to obtain the optical absorption spectrum of solid or liquid, dark or transparent samples. Previous studies report that assessing liver damage in rats produced by the modified resistant hepatocyte model (MRHM) is possible by analyzing their blood optical absorption spectrum. This study aimed to investigate, by PAS, the effect of phycocyanin obtained from spirulina on hepatic dysfunction. The optical absorption spectra analysis of the rat blood indicates the damage level induced by the MRHM group, being in concordance with the carried out biological conventional studies results, indicating an increase in the activity of hepatic enzymes, oxidative stress, Bax/Bcl2 ratio, cdk2, and AKT2 expression results, with a reduction in p53 expression. Also, PAS results suggest that phycocyanin decreases induced damage, due to the prevention of the Bax, AKT2, and p53 altered expression and the tumor progression in a HCC rat model.

show abstract

Microalgal phycocyanin productivity: strategies for phyco‐valorization

Querques

Cesta

Chiang

2015

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

Phyco-valorization is the exploitation of microalgae and microalgal chemicals as valuable products. This paper discusses the optimization of microalgal bioreactor-based systems for C-phycocyanin pigment production. Various aspects contributing to system development and enhancement of phycocyanin productivity are described. A wide range of potential microalgal species have been identified for phycocyanin production; the selection of a species for mass culturing can be determined by desired bioreactor trophic mode and symbiotic relations. Research has demonstrated that species amenability to local lighting and climatic conditions, and to variations in bioreactor substrate concentrations and operational parameters, have significant impact on phycocyanin production. The simultaneous optimization of all factors contributing to system productivity may be accomplished efficiently through process modelling. A summary of established models for microalgal phycocyanin production is presented. A suggested strategy for increasing economic viability of phycocyanin production systems is their application in integrated resource recovery. Through the incorporation of phycocyanin productivity optimization principles within a phycoremediation process, the valorization of waste resources may be achieved. The simultaneous economic potential and environmentally-forward concept of phyco-valorization through phycocyanin production is a promising application of microalgal biotechnology awaiting further development for industrial implementation.

show abstract

C‐Phycocyanin ameliorates 2‐acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice

Cited by 10 publications

References 31 publications

Phycobilins and Phycobiliproteins Used in Food Industry and Medicine

Phycobilins and Phycobiliproteins Used in Food Industry and Medicine

Hepatoprotective Effect Assessment of C-Phycocyanin on Hepatocellular Carcinoma Rat Model by Using Photoacoustic Spectroscopy

Microalgal phycocyanin productivity: strategies for phyco‐valorization

Contact Info

Product

Resources

About