C-reactive Protein –717A>G and –286C>T>A Gene Polymorphism and Ischemic Stroke

Abstract

Background:Inflammation plays a pivotal role in the formation and progression of ischemic stroke. Recently, more and more epidemiological studies have focused on the association between C-reactive protein (CRP) −717A > G and −286C > T > A genetic polymorphisms and ischemic stroke. However, the findings of these researches are not conclusive.Methods:We performed a meta-analysis to determine whether these two polymorphisms are associated with the risk of ischemic stroke. Eligible studies were identified from the database of PubMed, Medline, Embase, Web of Science, CNKI, Weipu, and Wanfang. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.Results:Four articles were included in our study, including 1926 cases and 2678 controls for −717A > G polymorphism, 652 cases and 1103 controls for −286C > T > A polymorphism. The results of meta-analysis showed that single nucleotide polymorphism (SNP) −717A > G was not significantly associated with the risk of ischemic stroke (GG vs. AA, OR = 1.12, 95% CI = 0.83–1.50, P = 0.207; GG + GA vs. AA, OR = 1.04, 95% CI = 0.93–1.17, P = 0.533; GG vs. GA + AA, OR = 1.10, 95% CI = 0.82–1.47, P = 0.220). Meta-analysis of SNP − 286C > T > A also demonstrated no statistical evidence of a significant association with the risk of ischemic stroke (AA vs. CC, OR = 0.86, 95% CI = 0.59–1.25, P = 0.348; AA vs. CC, OR = 0.92, 95% CI = 0.80–1.06, P = 0.609; AA vs. CC, OR = 0.89, 95% CI = 0.62–1.30, P = 0.374).Conclusions:This meta-analysis demonstrated little evidence to support a role of CRP gene −717A > G, −286C > T > A polymorphisms in ischemic stroke predisposition. However, to draw comprehensive and more reliable conclusions, further larger studies are needed to validate the association between CRP gene polymorphisms and ischemic stroke in various ethnic groups.

Association of C‐reactive protein gene polymorphisms with the risk of ischemic stroke: A systematic review and meta‐analysis

“…(2016), Liu et al. (2015), and Chen et al. (2014), respectively, reported the connection between CRP gene polymorphisms and IS susceptibility.…”

“…in CRP genes and IS (González-Giraldo et al, 2016), one showed scant evidence to support a role for CRP gene rs2794521 polymorphisms in ischemic stroke predisposition, (Liu et al, 2015) and one could provide the first proof that genetic variants (rs1130864 and rs2794521) within the CRP locus are associated with ischemic stroke. (Chen et al, 2014) According to the best of our knowledge, this is the first thorough meta-analysis and systematic review analyzing the association of five SNPs in the CRP gene with IS.…”

“…(2014), respectively, reported the connection between CRP gene polymorphisms and IS susceptibility. One of which showed no significant associations between these two polymorphisms (rs1800947 and rs1205) in CRP genes and IS (González‐Giraldo et al., 2016), one showed scant evidence to support a role for CRP gene rs2794521 polymorphisms in ischemic stroke predisposition, (Liu et al., 2015) and one could provide the first proof that genetic variants (rs1130864 and rs2794521) within the CRP locus are associated with ischemic stroke. (Chen et al., 2014)…”

Genomics of Atrial Fibrillation

“…Ischemic brain injury is characterized by inflammation. However, data regarding a polymorphism in the CRP gene, which has been reported in candidate gene analysis as an independent risk factor for stroke, have been conflicting [122, 123]. Other components of the inflammatory cascade studied include IL-1a, TNFα, IL-10, ICAM-1, though evidence has again been inconsistent [124–128] with studies limited by heterogeneity and small sample size.…”

Chemical differentiation of volatile compounds in crude and processed Atractylodis Macrocephalae Rhizoma by using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with multivariate data analysis

“…The volatile components of AMR play an important role to generate Siqi and Wuwei. Previous investigations have demonstrated that the volatile components of AMR have the effects of anti-inflammation [4], antiulcer [5], prevention of hypoglycemia [6], anti-oxidation [7], immunomodulation [8], antitumor cells [9], anti-aging, and hepatic protection [10,11]. Both crude AMR and its processed products (stir-frying with wheat bran) are frequently used clinically, and the appropriate processing methods can significantly alter the pharmacological properties of the original Chinese medicinal herbs, that is, the reduction of drug toxicity and the enhancement of pharmaceutical efficacy [12][13][14][15].…”