C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

Abstract

C-reactive protein (CRP) is a non-specific inflammatory marker, correlated with the severity and prognosis of ischemic stroke. We performed a retrospective study in which were included 81 patients diagnosed with acute ischemic stroke admitted between January and July 2017 in the Department of Neurology, Sibiu Emergency Clinical Hospital. CRP values were classified on three levels (0 - 5 mg / L, 5 - 50 mg / l and] 50 mg / l). We examined the correlation between CRP levels according to the type of ischemic (lacunar / territorial) stroke, the degree of motor deficit (quantified by the mRC scale), the associated risk factors and the mortality rate. PCR values above 50 mg / L were found in patients with territorial stroke (15%). Moderate motor deficits predominate, with PCR values ranging from 5-50 mg / L. The most important risk factors found in the patients included in our study were hypertension and atherosclerosis. We made correlations between these risk factors and the PCR values. In most cases with these two risk factors were recorded a mean PCR value (5-50 mg / L).For atherosclerosis the results were statistically significant, p = 0.021. Most patients (56%) had CRP levels ranging from 5 to 50 mg / L. These values recorded highest death rates. PCR it is an important marker of inflammation and it is important to be determined in all patients with acute ischemic stroke, especially which is thought to be correlated with the prognosis of these patients.

Evolution of the Thyroid Hormones and Thyreostimulin in Obese Children

“…This thyroiditis was although related with the increased concentrations of antigen present in the glandular parenchyma caused, maybe, by the iodine uptake as the thyroid dimensions were within normal ranges [27,28]. The presence of these antibodies may also be related to metabolic syndrome, nonalchoholic fatty liver disease [29] and liver fibrosis which can be assessed noninvasively [30,31] especially in children. In addition the negative feedback between TSH and the peripheral concentration of thyroid hormones could be dysfunctional in obese subjects explaining the high levels of TSH and peripheral thyroid hormones in obesity.…”

“…In addition the negative feedback between TSH and the peripheral concentration of thyroid hormones could be dysfunctional in obese subjects explaining the high levels of TSH and peripheral thyroid hormones in obesity. However, the degree of depression associated to these changes should be further investigated as long as other pathologies characterized also by brain inflammation may produce anxiety and depression [31,32].…”

Inflammatory Biomarkers in Febrile Seizure: A Comprehensive Bibliometric, Review and Visualization Analysis

“…Pro-inflammatory cytokines involved in febrile seizures' pathogenesis frequently reported in the research papers were (i) IL-1β, IL-6, IL-8, IL-12, IL-22, (TNF)-α, (ii) IFN-γ(important activator of macrophages involved in autoimmune disorders), (iii) transforming growth factor beta (TGF-β) suspected to trigger astrocytes' activity leading to EEG modified patterns toward seizures [2,17,54,55], and (iv) high mobility group box 1 protein (HGMB1) secreted by activated macrophages and monocytes [21]. However, the key interleukin involved in febrile seizures pathogenesis was IL-1β.…”

Study on the correlation between knee osteoarthritis and anxiety in patients aged over 55

“…Physical exercise is recommended in the treatment guidelines for osteoarthritis (61,62), having benefits in reducing pain, improving physical function (63,64), improving the mood (65), lowering the risk of developing other diseases (cardiovascular, metabolic, bone, neurodegenerative) (66,67). Thus, physical exercise inhibits nociception at the central level (68,69), at the local one (70) and at the systemic level and plays a role in reducing inflammation (83) and degenerative action at the joint level (71,72,73). In addition, physical exercise has the same results in reducing pain compared to pain-killers (73), but with very few adverse effects (74,75) However, it is necessary that the physiotherapist individualize the exercise, to adjust and modify the training parameters in order to manage the symptoms.…”