C-Reactive Protein/Albumin Ratio on the First Day after Surgery Predicts Short-Term Complications of Gastrectomy for Gastric Cancer

Liu, Zhijian; Chen, Li; Sun, Feng; Lv, Bingxin; Ge, Xiaolong; Shao, Lihua; Liu, Song

doi:10.1080/01635581.2022.2083190

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Importantly, CAR has shown a close association with the incidence of postoperative complications in gastric cancer patients. A recent study also evaluated CAR levels before and on the rst day after surgery, revealing that patients with CAR > 2.105 had signi cantly higher rates of postoperative complications and prolonged hospital stays compared to those with CAR < 2.105 [29].…”

Section: Discussionmentioning

confidence: 99%

Sodium aescinate reduces the incidence of Prolonged postoperative ileus after open surgery of advanced gastric cancer

Liu,

Sui,

Tao

et al. 2023

Preprint

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Background Prolonged postoperative ileus (PPOI) is one of the common complication postoperative complications of gastric cancer (GC) surgery, with limited preventive and treatment options currently available. This study aims to investigate the therapeutic efficacy of sodium aescinate in managing PPOI and identifying the related risk factors of PPOI in GC patients. Methods A total of 121 patients with advanced GC were enrolled and assigned to two groups to receive sodium aescinate or no treatment. Univariate and multivariate analyses were used to identify the PPOI-related risk factors in postoperative GC patients. Results The study revealed that postoperative sodium aescinate treatment independently served as a protective factor against PPOI (OR = 0.25, CI: 0.07–0.86, P = 0.028). Furthermore, the incidence of PPOI was significantly lower in patients who received sodium aescinate treatment compared to those who did not (15/66 VS 4/55, P = 0.020). Conclusions Postoperative administration of sodium aescinate reduces the occurrence of PPOI in patients with advanced GC.

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Section: Discussionmentioning

confidence: 99%

Sodium aescinate reduces the incidence of Prolonged postoperative ileus after open surgery of advanced gastric cancer

Liu,

Sui,

Tao

et al. 2023

Preprint

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“…Table 1 is consistent with the original CONUT scoring system in the literature [ 40 ]. Compared to other nutritional tools and parameters, such as the Glasgow prognostic score (GPS), modified GPS [ 41 , 42 ], PNI [ 43 , 44 ], AGR [ 45 , 46 ], systemic immune inflammation index [ 47–50 ], GNRI [ 51–53 ], and CAR [ 40 , 54 , 55 ], CONUT has the following advantages. First, CONUT is a standardized scoring system with clear scoring criteria ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of the controlling nutritional status (CONUT) score in patients with biliary tract cancer: a meta-analysis

Jiang,

Wang

2023

Annals of Medicine

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Background Previous reports have not reached consistent results regarding the prognostic significance of the controlling nutritional status (CONUT) score in biliary tract cancer (BTC). Therefore, the present meta-analysis was conducted to investigate the precise role of the CONUT score in predicting the prognosis of BTC. Methods Electronic platforms including Web of Science, PubMed, Cochrane Library, and Embase were comprehensively searched up to May 2, 2023. We also determined combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the role of the CONUT score in predicting the prognosis of patients with BTC. Results Ten studies involving 1,441 patients were included in the present study. Nine studies treated patients with surgical resection, and one study used percutaneous transhepatic biliary stenting (PTBS) plus 125I seed intracavitary irradiation. Based on the combined data, a higher CONUT score significantly predicted dismal overall survival (OS) (HR = 1.94, 95%CI = 1.41–2.66, p < 0.001), inferior recurrence-free survival (RFS) (HR = 1.79, 95%CI = 1.48–2.17, p < 0.001) in BTC, and low differentiation (OR = 1.57, 95%CI = 1.15–2.14, p = 0.004). Nonetheless, the CONUT score was not related to sex, lymph node metastasis, microvascular invasion, perineural invasion, distant metastasis, TNM stage, or tumor number in patients with BTC. Conclusion Higher CONUT scores significantly predicted worse OS and RFS in patients with BTC. Moreover, BTC patients with high CONUT scores tended to have poor tumor differentiation. The CONUT score could help clinicians stratify high-risk patients with BTC and devise individualized treatment plans.

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“…Various nutritional parameters based on the content of ALB in hematology are typically evaluate nutritional status of cancer cases, such as prognostic nutritional index (PNI), albumin/globulin ratio, geriatric nutritional risk index (GNRI), together with C-reactive protein/albumin [15,22,23]. Current studies generally agree that there is a clear correlation across malnutrition and survival in cancer cases.…”

Section: Discussionmentioning

confidence: 99%

Predictive value for advanced lung cancer inflammation index within short- /long-term outcomes of esophageal squamous cell carcinoma after minimally invasive esophagectomy cases： a propensity score matching study

Chen

et al. 2022

Preprint

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Introduction: Advanced lung cancer inflammation index (ALI) within esophageal squamous cell carcinoma (ESCC) importance is unclear. We aimed to investigate whether ALI is linked to poor short-term outcomes and long-term prognosis within cases of ESCC after minimally invasive esophagectomy (MIE). Methods: Kaplan-Meier survival assessment was applied for comparing cancer-specific survival (CSS) across different cohorts. Clinicopathological features across the two cohorts were eliminated by propensity score matching (PSM). We established a new model for predicting CSS by combining ALI and tumor-node-metastasis (TNM) staging according to Cox multivariate results. Time-dependent area under the curve (t-AUC) and decision curve analyses (DCA) evaluated predictive /clinical relevance capacities for this model. Results: Severe postoperative complication manifestations within low ALI cohort were significantly elevated compared to within high ALI cohort (25.3% vs 16.7, P=0.01), nil variations were identified across both cohorts after PSM (25.3% vs 18.3%, P = 0.06). Both, within overall cohort and the matched cohort, low ALI only significantly reduced the 5-year CSS in locally advanced ESCC patients (all P < 0.05) relative to high ALI. Further analysis demonstrated that patients within high ALI cohort were at increased risk for adverse postoperative CSS in most clinicopathological subgroups. Cox multivariate analysis demonstrated that TNM staging and ALI were variables that independently influenced adverse CSS in both cohorts (P < 0.05). Therefore, a new prediction model was established by combining these two factors. The t-AUC and DCA demonstrated that this model had a more accurate prediction effect and better clinical use value than the TNM stage alone. Conclusion: ALI proved to be an effective biological indicator of CSS after MIE in locally advanced ESCC patients. The combined application of the ALI and TNM model can thus improve the clinical prediction ability.

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C-Reactive Protein/Albumin Ratio on the First Day after Surgery Predicts Short-Term Complications of Gastrectomy for Gastric Cancer

Cited by 4 publications

References 26 publications

Sodium aescinate reduces the incidence of Prolonged postoperative ileus after open surgery of advanced gastric cancer

Sodium aescinate reduces the incidence of Prolonged postoperative ileus after open surgery of advanced gastric cancer

Prognostic role of the controlling nutritional status (CONUT) score in patients with biliary tract cancer: a meta-analysis

Predictive value for advanced lung cancer inflammation index within short- /long-term outcomes of esophageal squamous cell carcinoma after minimally invasive esophagectomy cases： a propensity score matching study

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