C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease

Menon, Vandana; Greene, Tom; Wang, Xuelei; Pereira, Arema A.; Marcovina, Santica M.; Beck, Gerald J.; Kusek, John W.; Collins, Alan J.; Levey, Andrew S.; Sarnak, Mark J.

doi:10.1111/j.1523-1755.2005.00455.x

Cited by 359 publications

(268 citation statements)

References 46 publications

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“…29 Inflammation and oxidative stress have been linked to the pathogenesis of plaque formation and plaque rupture, 30 both of which are associated with worse cardiovascular outcomes. 31 The present study found no differences in traditional risk factors between patients with and without cardiac events. Higher CRP levels were associated with cardiac events at 3 years of follow-up, but not after 1 year.…”

Section: Discussionmentioning

confidence: 52%

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Nakamura

Kawano

Nakajima

et al. 2019

Journal of Nuclear Cardiology

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Section: Discussionmentioning

confidence: 52%

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Nakamura

Kawano

Nakajima

et al. 2019

Journal of Nuclear Cardiology

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“…A albumina sérica foi o único parâmetro laboratorial analisado neste estudo, por ser ainda associada ao maior risco de mortalidade, embora alguns estudos sugiram que a proteína C-reativa seja um preditor primário dos níveis de albumina sérica em pacientes em hemodiálise (38). Estudos de Kubrusly et al, 2012, sugere que seja dosada albumina pós-diálise como melhor marcador do estado nutricional e de risco de mortalidade em pacientes com desnutrição leve ou risco nutricional, por apresentar menor confundimento de interpretação pela influência do estado de hiper-hidratação pré-diálise (39).…”

Section: Resultsunclassified

Análise de diferentes métodos de avaliação do estado nutricional de pacientes em hemodiálise

Ribeiro¹,

Araújo²,

Cunha³

et al. 2015

Rev Cuid

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RESUMENIntroducción: El paciente en diálisis debe ser evaluado por la nutrición y mantener seguimiento regular desde el inicio del tratamiento para así tener las mejores respuestas de intervenciones y dieta. Objetivo: Comparar la concordancia de la clasificación del estado nutricional de los pacientes con enfermedad renal crónica en hemodiálisis por medio de diferentes evaluaciones clínicas, antropométricas y parámetros bioquímicos. Materiales y Métodos: Estudio transversal con 90 pacientes de una clínica de diálisis, en la ciudad de Belo Horizonte, Brasil en 2010. Se recogieron los datos socioeconómicos, nutricionales, clínicos, bioquímicos y antropométricos. Resultados y Discusión: La frecuencia de desnutrición fue de 12,2% hasta 86,7% de acuerdo con diferentes parámetros de evaluación. En los análisis antropométricos, los hombres presentaran pliegues cutáneos más pequeños que las mujeres. Casi 40% de los pacientes tenían la clasificación de la desnutrición en los análisis de la circunferencia muscular del brazo, siendo aproximadamente 30% de hombres. Los valores promedios de índice de masa corporal se encontraban en el rango adecuado. Considerando la ingesta de energía y proteínas, 86,7% y 57,8% fueran clasificados como desnutridos, respectivamente. El valor promedio de albúmina fue 3,9 g / dl y la frecuencia de desnutrición varió 35,6% y 50%, según la referencia. Conclusiones: La alta frecuencia de pacientes con desnutrición de acuerdo con diferentes clasificaciones sugiere la necesidad de estandarización de indicadores, la observación cuidadosa y el seguimiento de las referencias utilizadas y también la necesidad de que los comités de evaluación en determinar nuevos puntos de corte para la mejor clasificación nutricional de esta población.

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“…Low serum albumin was defined as serum albumin Ͻ3.5 mg/dl (18 -20). Elevated CRP was defined as Ͼ3.0 mg/dl (21,22).…”

Section: Variablesmentioning

confidence: 99%

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as >60% of sites with attachment level >4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as <3.5 mg/dl, and with high CRP, defined as >3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P ‫؍‬ 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.

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C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease

Cited by 359 publications

References 46 publications

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Análise de diferentes métodos de avaliação do estado nutricional de pacientes em hemodiálise

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

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