C-Reactive protein and body mass index in women with pre-eclampsia

Kilic-Okman, Tulay; Küçük, Mert; Ekuklu, Galip

doi:10.1016/s0020-7292(03)00256-x

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…Thirty‐two studies in total reported on C‐reactive protein levels,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 of which 17 were applicable for meta‐analysis 21, 22, 23, 29, 30, 31, 32, 33, 34, 37, 38, 39, 41, 42, 47, 49, 50. A significantly higher C‐reactive protein was found in women with pre‐eclampsia than in non‐hypertensive controls ( Figure 2), and this correlation was stronger in severe than in mild pre‐eclampsia ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

“…Cardiovascular risk markers in pre-eclampsia C-reactive protein Thirty-two studies in total reported on C-reactive protein levels, of which 17 were applicable for meta-analysis. [21][22][23][29][30][31][32][33][34][37][38][39]41,42,47,49,50 A significantly higher C-reactive protein was found in women with preeclampsia than in non-hypertensive controls (Figure 2), and 90 L.J. Alma et al…”

Section: Study Characteristicsmentioning

confidence: 99%

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Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…demonstrated a positive correlation with increased BMI and risk of pre‐eclampsia but not with HELLP syndrome 30 . In a small sample‐size study, no correlation was found between increased serum CRP levels and BMI, but significantly higher levels of CRP have been found in women with pre‐eclampsia compared to normal healthy pregnant women 31 . Moreover, pregnancy itself in the absence of clinical infection contribute to an elevation of hs‐CRP levels 6,18,24,26 .…”

Section: Discussionmentioning

confidence: 98%

Association of maternal serum high sensitive C‐reactive protein level with body mass index and severity of pre‐eclampsia at third trimester

Ertaş

Kahyaoğlu

Yılmaz

et al. 2010

J of Obstet and Gynaecol

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“…Similarly, the presence of CV risk factors during the reproductive years may not have been evaluated in most of these patients, because the impact of such factors on gestation has been evident only recently. [23][24][25][26][27][28][29][30][31] Some reports do not differentiate between types of HPs, 7,11 and others show a greater association between preeclampsia and CV disease. 1,4,5,8,9 Based on these latter studies, our failure to characterize the different forms of HPs could have blunted their impact on coronary disease.…”

Section: Discussionmentioning

confidence: 99%

“…27 Based on the hypothesis that hypertension in pregnancy expresses underlying maternal conditions, we propose that proteinuric versus nonproteinuric HPs relate to CV complications through 2 different pathophysiologic pathways. In proteinuric HP (ie, preeclampsia), there may be an underlying endothelial dysfunction because of CV risk factors, [23][24][25][26][27][28][29][30][31][32]34,35,[37][38][39][40][41][42][43] which is exacerbated and clinically expressed by increased syncytiotrophoblast debris shedded into the maternal circulation. 44 -50 In nonproteinuric HP (ie, transient hypertension or exacerbation of an underlying hypertension), there is a restricted capacity to stimulate vasodilatory and antiaggregating factors (eg, prostacyclin, 51 tissue kallikrein, 52 and angiotensin- [1][2][3][4][5][6][7] 53 ); this limitation hampers the adaptation to the systemic hemodynamic changes of pregnancy 54 -57 and may favor CV disease later in life.…”

Section: Discussionmentioning

confidence: 99%

Association of Remote Hypertension in Pregnancy With Coronary Artery Disease

Valdés¹,

Quezada²,

Marchant³

et al. 2009

Hypertension

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Abstract-Because hypertensive pregnancies have been associated with increased cardiovascular disease, we aimed to identify whether angiographically characterized coronary artery disease differed in women with previous normotensive pregnancies or hypertensive pregnancies (HPs Key Words: hypertension in pregnancy Ⅲ preeclampsia Ⅲ coronary artery disease Ⅲ cardiovascular risks Ⅲ coronary angiography I ndirect evidence has linked preeclampsia, other forms of hypertension in pregnancy, and placentation-related defects to cardiovascular (CV) disease later in life. [1][2][3][4][5][6][7][8][9][10][11][12] Although most studies have used registry bases, one includes clinical follow-up, 10 one compares women with angiographically characterized coronary lesions with patients who only underwent clinical screening for coronary disease, 8 and another evaluates coronary calcification, a predictor of coronary artery disease. 11 A prospective study performed in a cohort of women with a precise classification of obstetric outcomes would be necessary to evaluate the tentative association between reproductive and CV complications, but because this is a relatively new finding, any ongoing or new study will need at least a couple of decades to be completed. Furthermore, included subjects would have to be left to the natural evolution of CV disease, and it is ethically inadmissible to abstain from CV preventive management.We decided to take an intermediate stance, by testing whether those subjects who had hypertensive pregnancies (HPs) developed earlier or more extensive coronary lesions than controls who had normotensive pregnancies (NPs). For this purpose, we evaluated the remote obstetric histories in women who underwent coronary angiography, the gold standard for defining coronary disease. MethodsThis investigation was a case-control observational retrospective study, with the results of coronary angiography as the dependent variable. Women undergoing coronary angiographies because of suspected coronary disease at Hospital Sótero del Río, in the southeast zone of Santiago, Chile, from January 1, 2006, to December 31, 2007, completed a questionnaire (please see the online data supplement at http://hyper.ahajournals.org) to determine their CV risk factors, including the following: family history; age of onset and end of menstrual cycles; hormonal replacement therapy; number of

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C-Reactive protein and body mass index in women with pre-eclampsia

Cited by 3 publications

References 4 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Association of maternal serum high sensitive C‐reactive protein level with body mass index and severity of pre‐eclampsia at third trimester

Association of Remote Hypertension in Pregnancy With Coronary Artery Disease

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